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New Paclitaxel Therapy Study Findings Have Been Reported by J.K. Lu and Co-Researchers (Free paclitaxel loaded PEGylated-paclitaxel nanoparticles:...

August 6, 2014



New Paclitaxel Therapy Study Findings Have Been Reported by J.K. Lu and Co-Researchers (Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting from Tianjin, People's Republic of China, by NewsRx journalists, research stated, "Previously, PEGylated paclitaxel (PEG-PTX) was found not favorable as a polymer prodrug because of its poor antitumor efficiency. But surprisingly, it was found in our study that PEG-PTX could form a novel nanoparticle system with free PTX."

The news correspondents obtained a quote from the research, "To address how this system works, we compared PTX loaded PEG-PTX nanoparticles (PEG-PTX/PTX) with PTX loaded PEG-PLA micelles (PEG-PLA/PTX) or PTX injection available (Taxol()) in vitro and in vivo. Firstly, it was found that PEG-PTX/PTX was more stable in aqueous solution than PEG-PLA/PTX in terms of PTX crystal formation and drug release. Then it was demonstrated that coumarin loaded PEG-PTX nanoparticles had a much higher uptake in MCF-7 cells compared to coumarin loaded PEG-PLA micelles. The in vivo imaging study revealed that DIR or DID (near infrared fluorescent substances) loaded PEG-PTX nanoparticles distributed more in tumors in MCF-7 tumor bearing mice than DIR or DID loaded PEG-PLA micelles and solvent system of Taxol(). In the efficacy study with MCF-7 tumor bearing mice, PEG-PTX/PTX showed significantly higher antitumor activity than PEG-PLA/PTX at the same PTX dosage. At the dose of 10 mg free PTX per kg, PEG-PTX/PTX displayed similar efficacy as Taxol() but less toxicity evaluated by the loss of body weight. With the increase of free PTX to 15 mg/kg, PEG-PTX/PTX showed significantly better efficacy than Taxol()."

According to the news reporters, the research concluded: "With favorable characteristics in stability, cellular uptake, cytotoxicity, biodistribution, safety and efficacy, PEG-PTX/PTX seems highly potential as a nanocarrier for PTX delivery."

For more information on this research see: Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo. International Journal of Pharmaceutics, 2014;471(1-2):525-535. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)

Our news journalists report that additional information may be obtained by contacting J.K. Lu, Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, People's Republic of China. Additional authors for this research include X.X. Chuan, H. Zhang, W.B. Dai, X.L. Wang, X.Q. Wang and Q. Zhang (see also Drugs and Therapies).

Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, Tianjin, Taxoids, Terpenes, Paclitaxel, Hydrocarbons, Nanoparticle, Cycloparaffins, Nanotechnology, Organic Chemicals, Mitotic Inhibitors, Drugs and Therapies, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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