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New Genetics and Hypersensitivity Study Findings Recently Were Reported by Researchers at CIBERER (The study of severe cutaneous drug...

August 6, 2014



New Genetics and Hypersensitivity Study Findings Recently Were Reported by Researchers at CIBERER (The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective)

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Immune System Diseases and Conditions is now available. According to news reporting out of Malaga, Spain, by NewsRx editors, research stated, "Stevens-Johnson syndrome and toxic epidermal necrolysis are severe hypersensitivity reactions, the majority of which are drug induced. The underlying mechanisms are not fully understood."

Our news journalists obtained a quote from the research from CIBERER, "Here, we review recent findings concerning both mechanistic and genetic factors related to these diseases and propose future approaches to unravel their complexity. Genome-wide association study studies have identified several variants in the human leukocyte antigen region associated with these reactions. These are highly dependent on the population studied and the triggering drug. The T-cell receptor repertoire of the patient is also key. Fas-Fas ligand interactions, perforin and granulysin have also been identified as important players. Furthermore, a high-throughput gene expression study has identified a number of genes that increase in expression in patients during the acute phase of these reactions. We review recent high-throughput studies on these diseases and suggest ways in which the data can be combined and reanalyzed using integrative systems biology techniques."

According to the news editors, the research concluded: "We also suggest future lines of research using recent technology that could shed further light on their underlying mechanisms."

For more information on this research see: The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective. Current Opinion in Allergy and Clinical Immunology, 2014;14(4):301-306. Current Opinion in Allergy and Clinical Immunology can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Current Opinion in Allergy and Clinical Immunology - journals.lww.com/co-allergy/pages/default.aspx)

Our news journalists report that additional information may be obtained by contacting J.R. Perkins, CIBERER, Malaga, Spain. Additional authors for this research include P. Ayuso, J.A. Cornejo-Garcia and J.A. Ranea (see also Immune System Diseases and Conditions).

Keywords for this news article include: Spain, Malaga, Europe, Genetics, Immunology, Drug Hypersensitivity, Immune System Diseases and Conditions

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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