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New Findings Reported from University of Tehran Describe Advances in Stem Cells (Enhanced chondrogenesis of human nasal septum derived progenitors on...

August 4, 2014



New Findings Reported from University of Tehran Describe Advances in Stem Cells (Enhanced chondrogenesis of human nasal septum derived progenitors on nanofibrous scaffolds)

By a News Reporter-Staff News Editor at Stem Cell Week -- Data detailed on Stem Cell Research have been presented. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "Topographical cues can be exploited to regulate stem cell attachment, proliferation, differentiation and function in vitro and in vivo. In this study, we aimed to investigate the influence of different nanofibrous topographies on the chondrogenic differentiation potential of nasal septum derived progenitors (NSP) in vitro."

The news reporters obtained a quote from the research from the University of Tehran, "Aligned and randomly oriented Ploy (L-lactide) (PLLA)/Polycaprolactone (PCL) hybrid scaffolds were fabricated via electrospinning. First, scaffolds were fully characterized, and then NSP were seeded on them to study their capacity to support stem cell attachment, proliferation and chondrogenic differentiation. Compared to randomly oriented nanofibers, aligned scaffolds showed a high degree of nanofiber alignment with much better tensile strength properties. Both scaffolds supported NSP adhesion, proliferation and chondrogenic differentiation. Despite the higher rate of cell proliferation on random scaffolds, a better chondrogenic differentiation was observed on aligned nanofibers as deduced from higher expression of chondrogenic markers such as collagen type II and aggrecan on aligned scaffolds."

According to the news reporters, the research concluded: "These findings demonstrate that electrospun constructs maintain NSP proliferation and differentiation, and that the aligned nanofibrous scaffolds can significantly enhance chondrogenic differentiation of nasal septum derived progenitors."

For more information on this research see: Enhanced chondrogenesis of human nasal septum derived progenitors on nanofibrous scaffolds. Materials Science & Engineering C-Materials for Biological Applications, 2014;40():445-454. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Stem Cell Research).

Our news correspondents report that additional information may be obtained by contacting A. Shafiee, Univ Tehran Med Sci, Imam Hosp, Brain & Spinal Injury Res Center, Tehran, Iran. Additional authors for this research include E. Seyedjafari, E.S. Taherzadeh, P. Dinarvand, M. Soleimani and J. Ai.

Keywords for this news article include: Iran, Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Tehran, Nanofiber, Nanofibrous, Bioengineering, Nanotechnology, Stem Cell Research, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Stem Cell Week


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