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New Cancer Gene Therapy Study Findings Have Been Reported by Researchers at Fudan University (Overexpression of long non-coding RNA HOTAIR predicts...

August 4, 2014



New Cancer Gene Therapy Study Findings Have Been Reported by Researchers at Fudan University (Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- A new study on Biotechnology is now available. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Although long non-coding RNAs (lncRNAs) are emerging as new regulators in the cancer paradigm, the involvement of lncRNAs in epithelial ovarian cancer (EOC) is just beginning to be studied. In this study, we focused on lncRNA HOX transcript antisense RNA (HOTAIR) and investigated its expression pattern, clinical significance, and biological function in EOC."

Our news journalists obtained a quote from the research from Fudan University, "HOTAIR expression in EOC tissues was examined and its correlation with clinicopathological factors and patient prognosis was analyzed. A series of in vitro and in vivo assays were performed to understand the role of HOTAIR in EOC metastasis. HOTAIR expression was elevated in EOC tissues, and HOTAIR levels were highly positively correlated with the FIGO stage, the histological grade of the tumor, lymph node metastasis, and reduced overall survival (OS) and disease-free survival (DFS). A multivariate analysis showed that HOTAIR expression is an independent prognostic factor of OS and DFS in patients with EOC. Additionally, the results of in vitro assays showed that the suppression of HOTAIR expression in the three highly metastatic EOC cell lines (SKOV3.ip1, H08910-PM, and HEY-A8) significantly reduced cell migration/invasion. The results of in vivo assays further confirmed the pro-metastatic effects of HOTAIR. Moreover, the pro-metastatic effects of HOTAIR were partially mediated by the regulation of certain matrix metalloproteinases (MMPs) and epithelial-to-mesenchymal transition (EMT)-related genes."

According to the news editors, the research concluded: "Our data suggest that HOTAIR plays a vital role in EOC metastasis and could represent a novel prognostic marker and potential therapeutic target in patients with EOC."

For more information on this research see: Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer. Gynecologic Oncology, 2014;134(1):121-128. Gynecologic Oncology can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Gynecologic Oncology - www.elsevier.com/wps/product/cws_home/622840)

The news correspondents report that additional information may be obtained from J.J. Qiu, Fudan University, Zhongshan Hosp, Dept. of Gen Surg, Shanghai 200032, People's Republic of China. Additional authors for this research include Y.Y. Lin, L.C. Ye, J.X. Ding, W.W. Feng, H.Y. Jin, Y. Zhang, Q. Li and K.Q. Hua (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Shanghai, Genetics, Oncology, Gynecology, Women's Health, Cancer Gene Therapy, Epithelial Ovarian Cancer, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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