New Biomimetics Study Findings Recently Were Reported by Researchers at Maringa State University (Interaction of eosin and its ester derivatives with aqueous biomimetic micelles: Evaluation of photodynamic potentialities)
By a News Reporter-Staff News Editor at Biotech Week -- New research on Biomimetics is the subject of a report. According to news reporting originating in Maringa, Brazil, by NewsRx journalists, research stated, "In this paper, the physicochemical and photophysical properties of xanthene dyes interacting with micelles were evaluated. Xanthenes are potential photosensitizers for photodynamic therapy."
The news reporters obtained a quote from the research from Maringa State University, "The dyes were eosin Y and its ester derivatives with methyl, butyl and decyl alkyl groups. In aqueous media at physiological pH eosin is present as dianionic protolytic form while its esters are monoanionic. Analysis of the water/octanol partition coefficient showed that the eosin is the most hydrophilic compound and the hydrophobicity increases as the alkyl chain of the ester increases: eosin < methyl ester < butyl ester < decyl ester. Computational calculations of the dipole moments, molecular volume, charge distribution, solvation energy and molecular orbital performed by the B3LYP/DGDZVP method and IEFPCM solvent model, allowed to justify the electronic absorption properties and its dependence with the dye environment. In order to mimic the interaction of these compounds with membranes, it was used micelles of sodium dodecyl sulfate (SOS), cetyl trimethylammonium bromide (CTAB) and polymeric micelles (Pluronics(®)) of P-123 and F-127. The binding constant between the xanthenes and micelles increased with the hydrophobicity of the dye in all evaluated systems. Furthermore, we observed the formation of pre-micellar aggregates when using cationic CTAB micelles due to electrostatic attraction. The iodide fluorescence quenching showed that the more hydrophobic photosensitizer were located deeply within the micelles. The fluorescence quantum yield values increased in the presence of surfactants, indicating protection against non-radiative deactivation. The dyes singlet oxygen quantum yield values suffered a small decrease when formulated in micelles, however they are still suitable for photodynamic applications."
According to the news reporters, the research concluded: "The results show that eosin and its ester derivatives have favorable characteristics for use in photodynamic therapy, particularly formulated in biocompatible polymeric surfactants such as Pluronics(®)."
For more information on this research see: Interaction of eosin and its ester derivatives with aqueous biomimetic micelles: Evaluation of photodynamic potentialities. Journal of Photochemistry and Photobiology A-Chemistry, 2014;287():30-39. Journal of Photochemistry and Photobiology A-Chemistry can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Biomimetics).
Our news correspondents report that additional information may be obtained by contacting B.M. Estevao, Maringa State University, Dept. of Quim, BR-87020900 Maringa, Parana, Brazil. Additional authors for this research include D.S. Pellosi, C.F. de Freitas, D. Vanzin, D.S. Franciscato, W. Caetano and N. Hioka.
Keywords for this news article include: Brazil, Maringa, Biomimetics, South America, Bioengineering, Bionanotechnology, Nanobiotechnology, Emerging Technologies
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