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Investigators from National Institute of Advanced Industrial Science and Technology (NIAIST) Have Reported New Data on Biological Factors...

August 5, 2014



Investigators from National Institute of Advanced Industrial Science and Technology (NIAIST) Have Reported New Data on Biological Factors [Bis(beta-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the ...]

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Biological Factors is the subject of a report. According to news reporting originating from Ibaraki, Japan, by NewsRx correspondents, research stated, "Glycosyl-[60]fullerenes were first used as decontaminants against ricin, a lactose recognition proteotoxin in the Ricinus communis family. A fullerene glycoconjugate carrying two lactose units was synthesized by a [3 + 2] cycloaddition reaction between C-60 and the azide group in 6-azidohexyl beta-lactoside per-O-acetate."

Our news editors obtained a quote from the research from the National Institute of Advanced Industrial Science and Technology (NIAIST), "A colloidal aqueous solution with brown color was prepared from deprotected bis(lactosyl)-C-60 and was found stable for more than 6 months keeping its red color. Upon mixing with an aqueous solution of Ricinus communis agglutinin (RCA(120)), the colloidal solution soon caused precipitations, while becoming colorless and transparent. In contrast, a solution of concanavalin A (Con A) caused no apparent change, indicating that the precipitation was caused specifically by carbohydrate-protein interactions."

According to the news editors, the research concluded: "This notable phenomenon was quantified by means of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and the results were discussed in terms of detection and decontamination of the deadly biological toxin in the Ricinus communis family."

For more information on this research see: Bis(beta-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the decontamination of biological toxins of the Ricinus communis family. Beilstein Journal of Organic Chemistry, 2014;10():1504-1512. Beilstein Journal of Organic Chemistry can be contacted at: Beilstein-Institut, Trakehner Strasse 7-9, Frankfurt Am Main, 60487, Germany. (BioMed Central - www.biomedcentral.com/; Beilstein Journal of Organic Chemistry - archive.biomedcentral.com/1860-5397)

The news editors report that additional information may be obtained by contacting H. Dohi, Natl Inst Adv Ind Sci & Technol, Nanosyst Res Inst, Tsukuba, Ibaraki 3058565, Japan. Additional authors for this research include T. Kanazawa, A. Saito, K. Sato, H. Uzawa, Y. Seto and Y. Nishida (see also Biological Factors).

Keywords for this news article include: Asia, Japan, Carbon, Ibaraki, Fullerenes, Nanotechnology, Biological Toxins, Biological Factors, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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