Investigators from Baqiyatallah University of Medical Sciences Release New Data on Reactive Oxygen Species (Developing a high performance superoxide dismutase based electrochemical biosensor for radiation dosimetry of thallium 201)
By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Reactive Oxygen Species have been presented. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "To develop a new biosensor for measurement of superoxide free radical generated in radiolysis reaction, three combinations of SOD-based biosensors including Au/Cys/SOD, Au/GNP/Cys/SOD and Au/GNP/Cys/SOD/Chit were fabricated. In these biosensors Au, GNP, Cys, SOD and Chit represent gold electrode, gold nano-particles, cysteine, superoxide dismutase and chitosan, respectively."
The news correspondents obtained a quote from the research from the Baqiyatallah University of Medical Sciences, "For biosensors fabrication, SOD, GNP, Cys and Chit were immobilized at the surface of gold electrode. Cyclic voltametry and chronoamperometry were utilized for evaluation of biosensors performances. The results showed that Au/GNP/Cys/SOD/Chit has significantly better responses compared to Au/Cys/SOD and Au/GNP/Cys/SOD. As a result, this biosensor was selected for dosimetry of ionizing radiation. For this purpose, thallium 201 at different volumes was added to buffer phosphate solution in electrochemical cell. To obtain analytical parameters of Au/GNP/Cys/SOD/Chit, calibration curve was sketched."
According to the news reporters, the research concluded: "The results showed that this biosensor has a linear response in the range from 0.5 to 4 Gy, detection limit 0.03 mu M. It also has a proper sensitivity (0.6038 nA/Gy), suitable long term stability and cost effective as well as high function for radiation dosimetry."
For more information on this research see: Developing a high performance superoxide dismutase based electrochemical biosensor for radiation dosimetry of thallium 201. Radiation Physics and Chemistry, 2014;102():128-134. Radiation Physics and Chemistry can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Radiation Physics and Chemistry - www.elsevier.com/wps/product/cws_home/331)
Our news journalists report that additional information may be obtained by contacting F. Salem, Baqiyatallah Univ Med Sci, Neurosci Res Center, Tehran, Iran. Additional authors for this research include H. Tavakoli, M. Sadeghi and A. Riazi (see also Reactive Oxygen Species).
Keywords for this news article include: Iran, Asia, Tehran, Anions, Chemistry, Biosensing, Electrolytes, Bioengineering, Electrochemical, Oxidoreductases, Bionanotechnology, Nanobiotechnology, Superoxide Dismutase, Enzymes and Coenzymes, Reactive Oxygen Species
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