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Investigators at Trinity College Discuss Findings in Itraconazole Therapy [Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of...

August 6, 2014

Investigators at Trinity College Discuss Findings in Itraconazole Therapy [Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole]

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting out of Dublin, Ireland, by NewsRx editors, research stated, "Itraconazole (ITR) is an antifungal drug with a limited bioavailability due to its poor aqueous solubility. In this study, ITR was used to investigate the impact of nanonisation and solid state change on drug's apparent solubility and dissolution."

Our news journalists obtained a quote from the research from Trinity College, "A bottom up approach to the production of amorphous ITR nanoparticles (NPs), composed of 100% drug, with a particle diameter below 250 nm, using heat induced evaporative antisolvent nanoprecipitation (HIEAN) from acetone was developed. The NPs demonstrated improved solubility and dissolution in simulated gastro-intestinal conditions when compared to amorphous ITR microparticles. The incorporation of polyethylene glycol (PEG) or its methoxylated derivative (MPEG) as a stabiliser enabled the production of smaller NPs with narrower particle size distribution and enhanced apparent solubility. MPEG stabilised NPs gave the greatest ITR supersaturation levels (up to 11.6 +/- 0.5 mu g/ml) in simulated gastric fluids. The stabilising polymer was in an amorphous state."

According to the news editors, the research concluded: "Dynamic vapour sorption data indicated no solid state changes in NP samples with water vapour at 25 degrees C, while crystallisation was apparent at 50 degrees C. HIEAN proved to be an efficient method of production of amorphous ITR NPs, with or without addition of a polymeric stabiliser, with enhanced pharmaceutical properties."

For more information on this research see: Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole. International Journal of Pharmaceutics, 2014;471(1-2):400-411. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; International Journal of Pharmaceutics -

Our news journalists report that additional information may be obtained by contacting N.A. Mugheirbi, Trinity College Dublin, Sch Pharm & Pharmaceut Sci, Dublin 2, Ireland. Additional authors for this research include K.J. Paluch and L. Tajber (see also Drugs and Therapies).

Keywords for this news article include: Antiinfectives, Pharmaceuticals, Dublin, Europe, Ireland, Itraconazole, Nanotechnology, Azole Antifungals, Nanoprecipitation, Drugs and Therapies, Emerging Technologies

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Source: Biotech Week

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