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Investigators at Max-Planck-Institute Describe Findings in Breast Cancer (Highly Sensitive Single Domain Antibody-Quantum Dot Conjugates for...

August 5, 2014



Investigators at Max-Planck-Institute Describe Findings in Breast Cancer (Highly Sensitive Single Domain Antibody-Quantum Dot Conjugates for Detection of HER2 Biomarker in Lung and Breast Cancer Cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology have been published. According to news reporting originating from Gottingen, Germany, by NewsRx correspondents, research stated, "Despite the widespread availability of immunohistochemical and other methodologies for screening and early detection of lung and breast cancer biomarkers, diagnosis of the early stage of cancers can be difficult and prone to error. The identification and validation of early biomarkers specific to lung and breast cancers, which would permit the development of more sensitive methods for detection of early disease onset, is urgently needed."

Our news editors obtained a quote from the research from Max-Planck-Institute, "In this paper, ultra-small and bright nanoprobes based on quantum dots (QDs) conjugated to single domain anti-HER2 (human epidermal growth factor receptor 2) antibodies (sdAbs) were applied for immunolabeling of breast and lung cancer cell lines, and their performance was compared to that of anti-HER2 monoclonal antibodies conjugated to conventional organic dyes Alexa Fluor 488 and Alexa Fluor 568. The sdAbs-QD conjugates achieved superior staining in a panel of lung cancer cell lines with differential HER2 expression."

According to the news editors, the research concluded: "This shows their outstanding potential for the development of more sensitive assays for early detection of cancer biomarkers."

For more information on this research see: Highly Sensitive Single Domain Antibody-Quantum Dot Conjugates for Detection of HER2 Biomarker in Lung and Breast Cancer Cells. ACS Nano, 2014;8(6):5682-5695. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)

The news editors report that additional information may be obtained by contacting T.Y. Rakovich, Max Planck Inst Expt Med, D-37075 Gottingen, Germany. Additional authors for this research include O.K. Mahfoud, B.M. Mohamed, A. Prina-Mello, K. Crosbie-Staunton, T. Van den Broeck, L. De Kimpe, A. Sukhanova, D. Baty, A. Rakovich, S.A.Maier, F. Alves, F. Nauwelaers, I. Nabiev, P. Chames and Y. Volkov (see also Oncology).

Keywords for this news article include: Antibodies, Europe, Germany, Oncology, Gottingen, Immunology, Quantum Dots, Breast Cancer, Blood Proteins, Nanotechnology, Women's Health, Immunoglobulins, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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