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Findings on Prostatic Secretory Proteins Reported by Researchers at National Institute of Biomedical Imaging and Bioengineering (Gold...

August 5, 2014



Findings on Prostatic Secretory Proteins Reported by Researchers at National Institute of Biomedical Imaging and Bioengineering (Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins. According to news reporting originating in Bethesda, Maryland, by NewsRx journalists, research stated, "It is still in high demand to develop extremely sensitive and accurate clinical tools for biomarkers of interest for early diagnosis and monitoring of diseases. In this report, we present a highly sensitive and compatible gold nanoparticle (AuNP)-based fluorescence-activatable probe for sensing ultralow levels of prostate-specific antigen (PSA) in patient serum samples."

The news reporters obtained a quote from the research from the National Institute of Biomedical Imaging and Bioengineering, "The limit of detection of the newly developed probe for PSA was pushed down to 0.032 pg/mL, which is more than 2 orders of magnitude lower than that of the conventional fluorescence probe. The ultrahigh sensitivity of this probe was attributed to the high loading efficiency of the dyes on AuNP surfaces and high fluorescence quenching-unquenching abilities of the dye-AuNP pairs."

According to the news reporters, the research concluded: "The efficiency and robustness of this probe were investigated in patient serum samples, demonstrating the great potential of this probe in real-world applications."

For more information on this research see: Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen. Acs Nano, 2013;7(6):5568-76. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)

Our news correspondents report that additional information may be obtained by contacting D. Liu, Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States. Additional authors for this research include X. Huang, Z. Wang, A. Jin, X. Sun, L. Zhu, F. Wang, Y. Ma, G. Niu, A.R. Hight Walker and X. Chen (see also Proteins).

Keywords for this news article include: Bethesda, Maryland, Immunology, United States, Nanotechnology, Neoplasm Antigens, Gold Nanoparticles, Emerging Technologies, Biological Tumor Markers, North and Central America, Prostate Specific Antigen, Prostatic Secretory Proteins.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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