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Findings on Natural Product Chemistry Detailed by F. Hufsky and Co-Authors (New kids on the block: novel informatics methods for natural product...

August 8, 2014



Findings on Natural Product Chemistry Detailed by F. Hufsky and Co-Authors (New kids on the block: novel informatics methods for natural product discovery)

By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting from Jena, Germany, by NewsRx journalists, research stated, "Covering:2008 to 2014 Mass spectrometry is a key technology for the identification and structural elucidation of natural products. Manual interpretation of the resulting data is tedious and time-consuming, so methods for automated analysis are highly sought after."

The news correspondents obtained a quote from the research, "In this review, we focus on four recently developed methods for the detection and investigation of small molecules, namely MetFrag/MetFusion, ISIS, FingerID, and FT-BLAST. These methods have the potential to significantly advance the field of computational mass spectrometry for the research of natural products. For example, they may help with the dereplication of compounds at an early stage of the drug discovery process; that is, the detection of molecules that are identical or highly similar to known drugs or drug leads."

According to the news reporters, the research concluded: "Furthermore, when a potential drug lead has been determined, these tools may help to identify it and elucidate its structure."

For more information on this research see: New kids on the block: novel informatics methods for natural product discovery. Natural Product Reports, 2014;31(6):807-17. (Royal Society of Chemistry - www.rsc.org/; Natural Product Reports - pubs.rsc.org/en/journals/journalissues/np)

Our news journalists report that additional information may be obtained by contacting F. Hufsky, Lehrstuhl fur Bioinformatik, Friedrich-Schiller-Universitat Jena, Ernst-Abbe-Platz 2, 07743 Jena, Germany. Additional authors for this research include K. Scheubert and S. Bocker (see also Drugs and Therapies).

Keywords for this news article include: Jena, Europe, Germany, Drugs and Therapies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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