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Findings in Gliomas Reported from Donghua University (Magnetic resonance imaging of glioma with novel APTS-coated superparamagnetic iron oxide...

August 4, 2014



Findings in Gliomas Reported from Donghua University (Magnetic resonance imaging of glioma with novel APTS-coated superparamagnetic iron oxide nanoparticles)

By a News Reporter-Staff News Editor at Clinical Oncology Week -- Investigators publish new report on Oncology. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "We report in vitro and in vivo magnetic resonance (MR) imaging of C6 glioma cells with a novel acetylated 3-aminopropyltrimethoxysilane (APTS)-coated iron oxide nanoparticles (Fe3O4 NPs). In the present study, APTS-coated Fe3O4 NPs were formed via a one-step hydrothermal approach and then chemically modified with acetic anhydride to generate surface charge-neutralized NPs."

The news reporters obtained a quote from the research from Donghua University, "Prussian blue staining and transmission electron microscopy (TEM) data showed that acetylated APTS-coated Fe3O4 NPs can be taken up by cells. Combined morphological observation, cell viability, and flow cytometric analysis of the cell cycle indicated that the acetylated APTS-coated Fe3O4 NPs did not significantly affect cell morphology, viability, or cell cycle, indicating their good biocompatibility. Finally, the acetylated APTS-coated Fe3O4 nanoparticles were used in magnetic resonance imaging of C6 glioma. Our results showed that the developed acetylated APTS-coated Fe3O4 NPs can be used as an effective labeling agent to detect C6 glioma cells in vitro and in vivo for MR imaging."

According to the news reporters, the research concluded: "The results from the present study indicate that the developed acetylated APTS-coated Fe3O4 NPs have a potential application in MR imaging."

For more information on this research see: Magnetic resonance imaging of glioma with novel APTS-coated superparamagnetic iron oxide nanoparticles. Nanoscale Research Letters, 2014;9():1-11. Nanoscale Research Letters can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Nanoscale Research Letters - www.springerlink.com/content/1931-7573/)

Our news correspondents report that additional information may be obtained by contacting K.G. Li, Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, People's Republic of China. Additional authors for this research include M.W. Shen, L.F. Zheng, J.L. Zhao, Q.M. Quan, X.Y. Shi and G.X. Zhang (see also Oncology).

Keywords for this news article include: Asia, Glioma, Shanghai, Oncology, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Clinical Oncology Week


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