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Findings from Y. Chen et al Has Provided New Information about Cancer Therapy (Stepwise encapsulation and controlled two-stage release system for...

August 6, 2014



Findings from Y. Chen et al Has Provided New Information about Cancer Therapy (Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Oncology. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method."

The news reporters obtained a quote from the research, "The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH=7.4) at 37.5 degrees C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies."

According to the news reporters, the research concluded: "MTT (3-[ 4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDPloaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded."

For more information on this research see: Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum. International Journal of Nanomedicine, 2014;9():3175-3182. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).

Our news correspondents report that additional information may be obtained by contacting Y. Chen, Shanghai Inst Qual Inspect & Technical Res, Shanghai, People's Republic of China. Additional authors for this research include Q. Li and Q.S. Wu.

Keywords for this news article include: Asia, Therapy, Shanghai, Oncology, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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