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Findings from University of California in the Area of Viral RNA Described (Screening for inhibitors of the hepatitis C virus internal ribosome entry...

August 6, 2014



Findings from University of California in the Area of Viral RNA Described (Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Viral RNA have been published. According to news reporting out of La Jolla, California, by NewsRx editors, research stated, "The highly conserved internal ribosome entry site (IRES) of hepatitis C virus (HCV) regulates translation of the viral RNA genome and is essential for the expression of HCV proteins in infected host cells. The structured subdomain IIa of the IRES element is the target site of recently discovered benzimidazole inhibitors that selectively block viral translation through capture of an extended conformation of an RNA internal loop."

Our news journalists obtained a quote from the research from the University of California, "Here, we describe the development of a FRET-based screening assay for similarly acting HCV translation inhibitors. The assay relies on monitoring fluorescence changes that indicate rearrangement of the RNA target conformation upon ligand binding. Screening of a small pilot set of potential RNA binders identified a benzoxazole scaffold as a ligand that bound selectively to IIa IRES target and was confirmed as an inhibitor of in vitro viral translation."

According to the news editors, the research concluded: "The screening approach outlined here provides an efficient method to discover HCV translation inhibitors that may provide leads for the development of novel antiviral therapies directed at the highly conserved IRES RNA."

For more information on this research see: Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA. Bioorganic & Medicinal Chemistry, 2013;21(20):6139-44. (Elsevier - www.elsevier.com; Bioorganic & Medicinal Chemistry - www.elsevier.com/wps/product/cws_home/129)

Our news journalists report that additional information may be obtained by contacting S. Zhou, Dept. of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States. Additional authors for this research include K.D. Rynearson, K. Ding, N.D. Brunn and T. Hermann (see also Viral RNA).

Keywords for this news article include: Therapy, La Jolla, Genetics, Cytoplasm, Hepatitis, Ribosomes, Viral RNA, California, Organelles, United States, Liver Diseases, Gastroenterology, Infectious Disease, Cellular Structures, Intracellular Space, North and Central America, Digestive System Diseases.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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