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Findings from State University of New York Broadens Understanding of Experimental Pharmacology (Transient receptor potential canonical 7: a...

August 8, 2014



Findings from State University of New York Broadens Understanding of Experimental Pharmacology (Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel)

By a News Reporter-Staff News Editor at Drug Week -- Current study results on Drugs and Therapies have been published. According to news reporting out of Albany, New York, by NewsRx editors, research stated, "Transient receptor potential canonical 7 (TRPC7) channel is the seventh member of the mammalian TRPC channel family. TRPC7 mRNA, protein, and channel activity have been detected in many tissues and organs from the mouse, rat, and human."

Our news journalists obtained a quote from the research from the State University of New York, "TRPC7 has high sequence homology with TRPC3 and TRPC6, and all three channels are activated by membrane receptors that couple to isoforms of phospholipase C (PLC) and mediate non-selective cation currents. TRPC7, along with TRPC3 and TRPC6, can be activated by direct exogenous application of diacylglycerol (DAG) analogues and by pharmacological maneuvers that increase endogenous DAG in cells. TRPC7 shows distinct properties of activation, such as constitutive activity and susceptibility to negative regulation by extracellular Ca(2+) and by protein kinase C. TRPC7 can form heteromultimers with TRPC3 and TRPC6."

According to the news editors, the research concluded: "Although TRPC7 remains one of the least studied TRPC channel, its role in various cell types and physiological and pathophysiological conditions is beginning to emerge."

For more information on this research see: Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel. Handbook of Experimental Pharmacology, 2014;222():189-204 (see also Drugs and Therapies).

Our news journalists report that additional information may be obtained by contacting X. Zhang, Nanobioscience Constellation, The State University of New York (SUNY), College of Nanoscale Science and Engineering (CNSE), 257 Fuller Road, Albany, NY, 12203, United States.

Keywords for this news article include: Albany, New York, United States, Drugs and Therapies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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