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Findings from Sichuan University Reveals New Findings on Cisplatin Therapy (Incorporation of cisplatin into PEG-wrapped ultrapurified...

August 6, 2014



Findings from Sichuan University Reveals New Findings on Cisplatin Therapy (Incorporation of cisplatin into PEG-wrapped ultrapurified large-inner-diameter MWCNTs for enhanced loading efficiency and release profile)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting out of Chengdu, People's Republic of China, by NewsRx editors, research stated, "The efficacy of carbon nanotubes based drug delivery systems (DDSs) has long been compromised by low drug loading efficiency and rapid release profile, especially for drugs encapsulated inside nanotubes. To address these deficiencies, the large-inner-diameter multi-walled carbon nanotubes (LID-MWCNTs) were employed to synthesize an innovative cisplatin (CDDP)-loaded DDS."

Our news journalists obtained a quote from the research from Sichuan University, "A multi-step purification and oxidation procedure was developed to achieve ultrapurified oxidized LID-MWCNTs prior to entrapping CDDP. High molecular weight polyethylene glycol (PEG) was grafted onto the nanotubes to partially block the exit paths of drugs. As assessed by TGA and ICP-OES analyses, CDDP loading efficiency of resulting DDS was as high as 100.12%, and sustained release profile was obtained. Finally, the anticancer activity on CAL-27 cells was evaluated, and enhanced inhibition effect (IC50 values 3.93 mu g/ml) was recorded."

According to the news editors, the research concluded: "The successful inner-cavity-loading of LID-MWCNTs also provides a basis for establishing more complicated multi-functional DDSs."

For more information on this research see: Incorporation of cisplatin into PEG-wrapped ultrapurified large-inner-diameter MWCNTs for enhanced loading efficiency and release profile. International Journal of Pharmaceutics, 2014;471(1-2):157-165. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)

Our news journalists report that additional information may be obtained by contacting L. Sui, Sichuan University, West China Hosp Stomatol, Dept. of Prosthodont, Chengdu 610041, People's Republic of China. Additional authors for this research include T. Yang, P. Gao, A. Meng, P.T. Wang, Z.Z. Wu and J. Wang (see also Drugs and Therapies).

Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, Chengdu, Nanotube, Cisplatin, Nanotechnology, Alkylating Agents, Chlorine Compounds, Nitrogen Compounds, Platinum Compounds, Drugs and Therapies, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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