Findings from Fujian Medical University in the Area of Biosensing Reported (A novel nanocomposite matrix based on graphene oxide and ferrocene-branched organically modified sol-gel/chitosan for biosensor application)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Biosensing have been published. According to news reporting originating in Fuzhou, People's Republic of China, by NewsRx journalists, research stated, "A novel platform for the fabrication of a glucose biosensor was successfully constructed by entrapping glucose oxidase (GOD) in a ferrocene (Fc)-branched organically modified silica material (ormosil)/chitosan (CS)/graphene oxide (GO) nanocomposite. The morphology, structure, and electrochemistry of the nanocomposite were characterized by transmission electron microscopy, X-ray powder diffraction, UV-vis spectroscopy, Fourier transform infrared spectroscopy, and electrochemical techniques."
The news reporters obtained a quote from the research from Fujian Medical University, "Results demonstrated that the proposed electrochemical platform not only provided an excellent microenvironment to maintain the bioactivity of the immobilized enzyme, but also effectively prevented the leakage of both the enzyme and mediator from the matrix and retained the electrochemical activity of Fc. Furthermore, dispersing GO within the Fc-branched ormosil/CS matrix could significantly improve the stability of GO and make it exhibit a positive charge, which was more favorable for the further immobilization of biomolecules, such as GOD, with higher loading. Moreover, it could also improve the conductivity of the matrix film and facilitate the electron shuttle between the mediator and electrode. Under optimal conditions, the designed biosensor to glucose exhibited a wide and useful linear range of 0.02 to 5.39 mM with a low detection limit of 6.5 mu M. The value of K (M) (app) was 4.21 mM, indicating that the biosensor possesses higher biological affinity to glucose."
According to the news reporters, the research concluded: "The present approach could be used efficiently for the linkage of other redox mediators and immobilize other biomolecules in the process of fabricating novel biosensors."
For more information on this research see: A novel nanocomposite matrix based on graphene oxide and ferrocene-branched organically modified sol-gel/chitosan for biosensor application. Journal of Solid State Electrochemistry, 2014;18(7):1941-1949. Journal of Solid State Electrochemistry can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Solid State Electrochemistry - www.springerlink.com/content/1432-8488/)
Our news correspondents report that additional information may be obtained by contacting H.P. Peng, Fujian Med Univ, Nano Med Technol Res Inst, Fuzhou 350004, People's Republic of China. Additional authors for this research include Z.J. Huang, Y.J. Zheng, W. Chen, A.L. Liu and X.H. Lin (see also Biosensing).
Keywords for this news article include: Asia, Fuzhou, Chemistry, Biosensing, Bioengineering, Electrochemical, Bionanotechnology, Nanobiotechnology, People's Republic of China
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC