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Data on Microtubule-Associated Proteins Detailed by Researchers at Institute of Molecular Genetics (Gold nanoparticle-based immuno-PCR for detection...

August 5, 2014



Data on Microtubule-Associated Proteins Detailed by Researchers at Institute of Molecular Genetics (Gold nanoparticle-based immuno-PCR for detection of tau protein in cerebrospinal fluid)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteins have been published. According to news reporting out of Prague, Czech Republic, by NewsRx editors, research stated, "Tau protein in cerebrospinal fluid (CSF) is an important biomarker of Alzheimer's disease and some other brain diseases. Enzyme-linked immunosorbent assays (ELISAs) have been mostly used for quantification of tau and other biomarkers in CSF."

Our news journalists obtained a quote from the research from the Institute of Molecular Genetics, "However, these assays do not have sufficient sensitivity and dynamic range. In this study we tested the suitability of gold nanoparticles functionalized with tau-specific monoclonal antibody and oligonucleotide template for immuno-polymerase chain reaction (Nano-iPCR) quantification of tau protein in human CSF samples and compared it with ELISA, either commercial or newly developed with tyramide signal amplification."

According to the news editors, the research concluded: "Our data indicate that Nano-iPCR is superior in sensitivity and detection range to ELISA in tau protein detection."

For more information on this research see: Gold nanoparticle-based immuno-PCR for detection of tau protein in cerebrospinal fluid. Journal of Immunological Methods, 2014;406():137-42. (Elsevier - www.elsevier.com; Journal of Immunological Methods - www.elsevier.com/wps/product/cws_home/506022)

Our news journalists report that additional information may be obtained by contacting L. Stegurova, Laboratory of Signal Transduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, CZ-142 20, Prague 4, Czech Republic. Additional authors for this research include E. Draberova, A. Bartos, P. Draber, D. Ripova and P. Draber (see also Proteins).

Keywords for this news article include: Prague, Europe, tau Proteins, Czech Republic, Nanotechnology, Gold Nanoparticles, Cytoskeletal Proteins, Emerging Technologies, Microtubule Associated Proteins.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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