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Bar-Ilan University Details Findings in Neurons (Neuronal growth on L- and D-cysteine self-assembled monolayers reveals neuronal chiral sensitivity)

August 5, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Neurons. According to news originating from Ramat Gan, Israel, by NewsRx correspondents, research stated, "Studying the interaction between neuronal cells and chiral molecules is fundamental for the design of novel biomaterials and drugs. Chirality influences all biological processes that involve intermolecular interaction."

Our news journalists obtained a quote from the research from Bar-Ilan University, "One common method used to study cellular interactions with different enantiomeric targets is the use of chiral surfaces. Based on previous studies that demonstrated the importance of cysteine in the nervous system, we studied the effect of L-and D-cysteine on single neuronal growth. L-Cysteine, which normally functions as a neuromodulator or a neuroprotective antioxidant, causes damage at elevated levels, which may occur post trauma. In this study, we grew adult neurons in culture enriched with L-and D-cysteine as free compounds or as self-assembled monolayers of chiral surfaces and examined the effect on the neuronal morphology and adhesion. Notably, we have found that exposure to the L-cysteine enantiomer inhibited, and even prevented, neuronal attachment more severely than exposure to the D-cysteine enantiomer. Atop the L-cysteine surfaces, neuronal growth was reduced and degenerated. Since the cysteine molecules were attached to the surface via the thiol groups, the neuronal membrane was exposed to the molecular chiral site."

According to the news editors, the research concluded: "Thus, our results have demonstrated high neuronal chiral sensitivity, revealing chiral surfaces as indirect regulators of neuronal cells and providing a reference for studying chiral drugs."

For more information on this research see: Neuronal growth on L- and D-cysteine self-assembled monolayers reveals neuronal chiral sensitivity. Acs Chemical Neuroscience, 2014;5(5):370-6. (American Chemical Society -; Acs Chemical Neuroscience -

The news correspondents report that additional information may be obtained from K. Baranes, Faculty of Engineering, Dept. of Chemistry, Gonda Multidisciplinary Brain Research Center and ?Bar Ilan Institute of Nanotechnologies and Advanced Materials, Bar Ilan University , 5290002 Ramat Gan, Israel. Additional authors for this research include H. Moshe, N. Alon, S. Schwartz and O. Shefi (see also Neurons).

Keywords for this news article include: Asia, Cells, Israel, Neurons, Ramat Gan.

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Source: Life Science Weekly

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