Studies Conducted at Northwestern University on Endocytosis Recently Reported (Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates)
By a News Reporter-Staff News Editor at Science Letter -- A new study on Endocytosis is now available. According to news reporting out of Evanston, Illinois, by NewsRx editors, research stated, "Intracellular delivery of nucleic acids as gene regulation agents typically requires the use of cationic carriers or viral vectors, yet issues related to cellular toxicity or immune responses hamper their attractiveness as therapeutic candidates. The discovery that spherical nucleic acids (SNAs), polyanionic structures comprised of densely packed, highly oriented oligonucleotides covalently attached to the surface of nanoparticles, can effectively enter more than 50 different cell types presents a potential strategy for overcoming the limitations of conventional transfection agents."
Our news journalists obtained a quote from the research from Northwestern University, "Unfortunately, little is known about the mechanism of endocytosis of SNAs, including the pathway of entry and specific proteins involved. Here, we demonstrate that the rapid cellular uptake kinetics and intracellular transport of SNAs stem from the arrangement of oligonucleotides into a 3D architecture, which supports their targeting of class A scavenger receptors and endocytosis via a lipid-raft-dependent, caveolae-mediated pathway."
According to the news editors, the research concluded: "These results reinforce the notion that SNAs can serve as therapeutic payloads and targeting structures to engage biological pathways not readily accessible with linear oligonucleotides."
For more information on this research see: Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(19):7625-30. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
Our news journalists report that additional information may be obtained by contacting C.H. Choi, International Institute for Nanotechnology, Dept. of Chemistry, Northwestern University, Evanston, IL 60208, United States. Additional authors for this research include L. Hao, S.P. Narayan, E. Auyeung and C.A Mirkin (see also Endocytosis).
Keywords for this news article include: Evanston, Illinois, Endocytosis, United States, North and Central America.
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