News Column

Reports from University of Colorado Highlight Recent Findings in Nanodrops (Condensation Phase Diagrams for Lipid-Coated Perfluorobutane Microbubbles)

July 11, 2014

By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Nanodrops are presented in a new report. According to news reporting out of Boulder, Colorado, by NewsRx editors, research stated, "The goal of this study was to explore the thermodynamic conditions necessary to condense aqueous suspensions of lipid-coated gas-filled microbubbles into metastable liquid-filled nanodrops as well as the physicochemical mechanisms involved with this process. Individual perfluorobutane microbubbles and their lipid shells were observed as they were pressurized at 34.5 kPa s(-1) in a microscopic viewing chamber maintained at temperatures ranging from 5 to 75 degrees C. The microbubbles contracted under pressure, ultimately leading to either full dissolution or microbubble-to-nanodrop condensation."

Our news journalists obtained a quote from the research from the University of Colorado, "Temperature- pressure phase diagrams conveying condensation and stability transitions were constructed for microbubbles coated with saturated diacylphosphatidylcholine lipids of varying acyl chain length (C16 to C24). The onset of full dissolution was shifted to higher temperatures with the use of longer acyl chain lipids or supersaturated media. Longer chain lipid shells resisted both dissolution of the gas core and mechanical compression through a pronounced wrinkle-to-fold collapse transition. Interestingly, the lipid shell also provided a mechanical resistance to condensation, shifting the vapor-to-liquid transition to higher pressures than for bulk perfluorobutane. This result indicated that the lipid shell can provide a negative apparent surface tension under compression."

According to the news editors, the research concluded: "Overall, the results of this study will aid in the design and formulation of vaporizable fluorocarbon nanodrops for various applications, such as diagnostic ultrasound imaging, targeted drug delivery, and thermal ablation."

For more information on this research see: Condensation Phase Diagrams for Lipid-Coated Perfluorobutane Microbubbles. Langmuir, 2014;30(21):6209-6218. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Langmuir -

Our news journalists report that additional information may be obtained by contacting P.A. Mountford, University of Colorado, Mat Sci & Engn Program, Boulder, CO 80309, United States. Additional authors for this research include S.R. Sirsi and M.A. Borden (see also Nanodrops).

Keywords for this news article include: Boulder, Colorado, Nanodrops, United States, Nanotechnology, Emerging Technologies, North and Central America

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Source: Science Letter

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