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Findings from S.Q. Xiang and Co-Researchers Provides New Data on Hydrogen [Detection of a transient intramolecular hydrogen bond using (l)J(NH)...

July 11, 2014



Findings from S.Q. Xiang and Co-Researchers Provides New Data on Hydrogen [Detection of a transient intramolecular hydrogen bond using (l)J(NH) scalar couplings]

By a News Reporter-Staff News Editor at Science Letter -- Research findings on Hydrogen are discussed in a new report. According to news reporting from Gottingen, Germany, by NewsRx journalists, research stated, "Hydrogen bonds are essential for the structure, stability and folding of proteins. The identification of intramolecular hydrogen bonds, however, is challenging, in particular in transiently folded states."

The news correspondents obtained a quote from the research, "Here we studied the presence of intramolecular hydrogen bonds in the folding nucleus of the coiled-coil structure of the GCN4 leucine zipper. Using one-bond (l)JNH spin spin coupling constants and hydrogen/deuterium exchange, we demonstrate that a transient intramolecular hydrogen bond is present in the partially helical folding nucleus of GCN(16-31). The data demonstrate that lJNH couplings are a sensitive tool for the detection of transient intramolecular hydrogen bonds in challenging systems where the effective/useable protein concentration is low."

According to the news reporters, the research concluded: "This includes peptides at natural abundance but also uniformly labeled biomolecules that are limited to low concentrations because of precipitation or aggregation."

For more information on this research see: Detection of a transient intramolecular hydrogen bond using (l)J(NH) scalar couplings. Journal of Magnetic Resonance, 2014;243():93-97. Journal of Magnetic Resonance can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Journal of Magnetic Resonance - www.elsevier.com/wps/product/cws_home/622884)

Our news journalists report that additional information may be obtained by contacting S.Q. Xiang, Center Nanoscale Microscopy & Mol Physiol Brain CNMP, Gottingen, Germany (see also Hydrogen).

Keywords for this news article include: Gases, Europe, Germany, Elements, Hydrogen, Gottingen, Inorganic Chemicals

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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