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Data on Peroxisome Proliferator-Activated Receptors Reported by Researchers at Shandong University (Molecular Recognition of Agonist and Antagonist...

July 11, 2014



Data on Peroxisome Proliferator-Activated Receptors Reported by Researchers at Shandong University (Molecular Recognition of Agonist and Antagonist for Peroxisome Proliferator-Activated Receptor-alpha Studied by Molecular Dynamics Simulations)

By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Proteins. According to news reporting out of Jinan, People's Republic of China, by NewsRx editors, research stated, "Peroxisome proliferator activated receptor-alpha (PPAR-alpha) is a ligand-activated transcription factor which plays important roles in lipid and glucose metabolism. The aim of this work is to find residues which selectively recognize PPAR-alpha agonists and antagonists."

Our news journalists obtained a quote from the research from Shandong University, "To achieve this aim, PPAR-alpha/13M and PPAR-alpha/471 complexes were subjected to perform molecular dynamics simulations. This research suggests that several key residues only participate in agonist recognition, while some other key residues only contribute to antagonist recognition."

According to the news editors, the research concluded: "It is hoped that such work is useful for medicinal chemists to design novel PPAR-alpha agonists and antagonists."

For more information on this research see: Molecular Recognition of Agonist and Antagonist for Peroxisome Proliferator-Activated Receptor-alpha Studied by Molecular Dynamics Simulations. International Journal of Molecular Sciences, 2014;15(5):8743-8752. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Proteins).

Our news journalists report that additional information may be obtained by contacting M.Y. Liu, Shandong University, State Key Lab Microbial Technol, Jinan 250100, People's Republic of China. Additional authors for this research include L.S. Wang, X. Zhao and X. Sun.

Keywords for this news article include: Asia, Jinan, Physics, PPAR alpha, Nanotechnology, Molecular Dynamics, DNA-Binding Proteins, Emerging Technologies, Molecular Recognition, Transcription Factors, People's Republic of China, Cytoplasmic and Nuclear Receptors, Peroxisome Proliferator-Activated Receptors

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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