New Polyethylenes Study Findings Have Been Reported by Investigators at Fudan University (Polyethylene glycol modified magnetic carbon nanotubes as nanosorbents for the determination of methylprednisolone in rat plasma by high performance ...)
By a News Reporter-Staff News Editor at Science Letter -- Current study results on Polyethylenes have been published. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "In this paper, polyethylene glycol modified (PEGylated) magnetic carbon nanotubes were developed as solid-phase extraction nanosorbents for the determination of methylprednisolone in rat plasma. The procedure mainly involved two steps including preparation of PEGylated magnetic nanosorbents and bio-analysis."
The news reporters obtained a quote from the research from Fudan University, "Monodisperse magnetites (Fe3O4) anchored onto multi-walled carbon nanotubes (MWCNTs) were synthesized by a facile solvothermal synthesis method. The obtained MWCNTs-Fe3O4 nanomaterials were further non-covalently functionalized by a surfactant phospholipids-polyethylene glycol (DSPE-PEG). Owing to dispersibility and high enrichment ability, water-soluble PEGylated MWCNTs-Fe3O4 nanomaterials can provide more efficient way for the extraction of methylprednisolone than only MWCNTs-Fe3O4 used. The methylprednisolone could be easily extracted via pi-pi stacking interactions with PEGylated MWCNTs-Fe3O4. The captured methylprednisolone/nanosorbents were isolated from the matrix by placing a magnet, and desorbed by the elution solvent composed of acetonitrile. Extraction conditions such as amount of nanosorbents added, adsorption time, desorption solvent, and desorption time were investigated and optimized. The method recoveries were obtained from 88.2% to 92.9%. Limits of quantification and limits of detection of 0.01 and 0.005 mu g/mL were acquired, respectively. The precision ranged from 4.2% to 7.8% for within-day measurement, and for between-day variation was in the range of 5.5-9.0%. Moreover, the analytical performance obtained by PEGylated magnetic MWCNTs was compared with that of magnetic MWCNTs."
According to the news reporters, the research concluded: "The results indicated that the approach based on PEGylated magnetic MWCNTs was useful for the analysis of methylprednisolone in the complex plasma."
For more information on this research see: Polyethylene glycol modified magnetic carbon nanotubes as nanosorbents for the determination of methylprednisolone in rat plasma by high performance liquid chromatography. Journal of Chromatography A, 2014;1348():27-33. Journal of Chromatography A can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Chromatography A - www.elsevier.com/wps/product/cws_home/502688)
Our news correspondents report that additional information may be obtained by contacting P.F. Yu, Fudan University, Sch Pharm, Shanghai 201203, People's Republic of China. Additional authors for this research include H.W. Ma, Y. Shang, J. Wu and S. Shen (see also Polyethylenes).
Keywords for this news article include: Shanghai, People's Republic of China, Asia, Alkenes, Carbon Nanotubes, Emerging Technologies, Fullerenes, High-Performance Liquid Chromatography, Hydrocarbons, Imaging Technology, Nanomaterial, Nanotechnology, Organic Chemicals, Polyenes, Polyethylene Glycols, Polyethylenes
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