Adult stem cells that are required for regenerative medicine transplant therapies are biological, but not magical. However, many current regenerative medicine clinical trials may seem to treat them as if they were magical.
Many current clinical trials, as well as unsanctioned studies that constitute "stem cell tourism," are evaluating heterologous tissue stem cell transplantation as an approach to developing new regenerative medicine therapies. In reality, these are not regenerative therapies, because in these clinical settings multiplication of the transferred cells is not desirable at all. They are expected to provide a therapeutic effect by way of other properties that do not require their multiplication, which is the basis for the moniker "regenerative."
Paradoxically, some companies developing heterologous stem cell therapies state that the transplanted cells will eventually be cleared from the body (e.g.,
Instead of regenerating diseased and injured tissues by virtue of their specialized multiplication, the heterologous cells are being employed for envisioned general repair properties. Again, ironically, there is no good biological rationale to expect that functionally immature adult stem cells will have repair capabilities. However, they might produce progeny cells with such functions, but this would require their multiplication. These appear to be quite an inconsistent muddle of rationalizations.
The seemingly magical attitude taken by companies, investigators, and physicians pursuing these heterologous transplant therapies is really an illusion created by two limitations. First, the stem cells that are most readily obtained and multiplied are mesenchymal stem cells (MSCs), which are found in tissues like fat, bone marrow, skin, and joints, but are not the primary stem cells that form many of the organs and tissues in need of regenerative medicine treatments (e.g., pancreas, heart, nerves, liver). Second, although much research has been conducted with MSCs, what they might accomplish in human patients after heterologous transplantation can only be learned by conducting high-quality clinical trials.
Whether or not heterologous stem cell transplantation therapy, with all of its noted reservations, proves beneficial, extending homologous regenerative therapies – like bone marrow stem cell transplantation – to more organs and tissues is an important regenerative medicine goal. Contributing to achieving this goal is the core business of
The ASCTC recently announced the approval of a new patent for producing induced pluripotent stem cells more efficiently. The new patent has a foundation in the ACSTC's portfolio of patents for methods to multiply adult stem cells from diverse organs and tissues that are important targets for regenerative medicine therapies.
The lead adult stem cell expansion technology currently pursued by the company is for human liver adult stem cells. Produced in sufficient quantity, human liver stem cells could be used to produce functionally mature human liver cells called hepatocytes. Hepatocytes are essential for drug testing before advancing to clinical drug trials with patients. Current sources of these crucial drug testing cells are scarce, unreliable, and often of low quality. At manufacturing scale, the ASCTC's adult stem cell multiplication technology could make such limitations a thing of the past.
In sufficient quantity, manufactured human hepatocytes could also supply companies (e.g.,
ASCTC is now seeking investors for its human liver stem cell manufacturing business. Sherley, who funded the initiating human liver stem cell production research with a prestigious Director's Pioneer Award from the
The ASCTC's adult stem cell multiplication technology works for adult stem cells from a variety of different types of organs and tissues. So far, in addition to human liver, the company's intellectual property portfolio contains patents for rodent liver stem cells and hair follicle stem cells; and it has patents pending for human pancreatic stem cells, which have potential applications for cellular therapy for diabetes.
For addition information visit.
Read the full story at http://www.prweb.com/releases/2014/07/prweb12038220.htm
Most Popular Stories
- PBS Series Examines America's Demographic Shift
- California's Ban on Plastic Bags: What Now?
- Petri Likely Broke House Ethics Rules
- Americans Bet Big on Gambling Industry
- Exxon Gives Nod to Fracking Risks
- Morgan: 'Can't Believe' Wal-Mart Blaming Him
- Texas Sees Gains in Hispanic College Enrollment
- Wealth Gap Widens as Rich Spend More on Kids' Education
- Can You Be Fired for Using Medical Marijuana?
- Lack of Sea Ice Brings 35,000 Walruses Ashore