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Study Findings on Basal Cell Cancer Are Outlined in Reports from Ruhr University (Histopathological correlates of basal cell carcinoma in the slice...

July 28, 2014



Study Findings on Basal Cell Cancer Are Outlined in Reports from Ruhr University (Histopathological correlates of basal cell carcinoma in the slice and en face imaging modes of high-definition optical coherence tomography)

By a News Reporter-Staff News Editor at Clinical Oncology Week -- Investigators publish new report on Oncology. According to news reporting out of Bochum, Germany, by NewsRx editors, research stated, "High-definition optical coherence tomography (HD-OCT) scanners have recently been developed, providing significantly higher resolution than conventional OCT. To assess the relationship between recently defined histopathological HD-OCT correlates of basal cell carcinomas (BCC) and possible predictors for the most common tumour subtypes."

Our news journalists obtained a quote from the research from Ruhr University, "For HD-OCT imaging, we used the Skintell device. Twenty-five BCCs were histopathologically confirmed (including both vertical and horizontal haematoxylin and eosin and Alcian blue sectioning) and correlated with HD-OCT images. In the en face mode, lobulated nodules were seen in 21/25 BCCs (84%), peripheral rimming in 18/25 (72%), epidermal disarray in 18/25 (72%) and variably refractile stroma in 22/25 (88%). In the slice imaging mode, we observed destruction of layering in 19/25 (76%) BCCs. In both the slice and en face modes a significant correlation was observed between peritumoral rimming and grey/dark oval structures and lobulated nodules. Alcian blue stains showed peritumoral mucin deposits correlating with peripheral rimming around the tumour nodules. In a logistic regression model, we did not observe significant independent micromorphological HD-OCT predictors for either the solid or superficial BCC subtypes. In agreement with recent studies we have demonstrated that HD-OCT using the slice and en face imaging modes can visualize histopathological correlates of BCC, and potentially aid noninvasive diagnostics. However, using HD-OCT correlation it was not possible to predict the superficial or solid BCC subtypes."

According to the news editors, the research concluded: "For the first time we have shown that peripheral rimming in HD-OCT correlates with peritumoral mucin deposition."

For more information on this research see: Histopathological correlates of basal cell carcinoma in the slice and en face imaging modes of high-definition optical coherence tomography. British Journal of Dermatology, 2014;170(6):1358-1361. British Journal of Dermatology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; British Journal of Dermatology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2133)

Our news journalists report that additional information may be obtained by contacting T. Gambichler, Ruhr University of Bochum, Dept. of Dermatol, D-44791 Bochum, Germany. Additional authors for this research include I. Plura, P. Kampilafkos, K. Valavanis, M. Sand, F.G. Bechara and M. Stucker (see also Oncology).

Keywords for this news article include: Bochum, Germany, Europe, Basal Cell Carcinoma, Imaging Technology, Oncology, Optical Coherence Tomography

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Clinical Oncology Week


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