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Study Findings from Nankai University Provide New Insights into Peptides and Proteins (Aminophenylboronic-Acid-Conjugated Polyacrylic Acid-Mn-Doped...

July 29, 2014



Study Findings from Nankai University Provide New Insights into Peptides and Proteins (Aminophenylboronic-Acid-Conjugated Polyacrylic Acid-Mn-Doped ZnS Quantum Dot for Highly Sensitive Discrimination of Glycoproteins)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins. According to news reporting out of Tianjin, People's Republic of China, by NewsRx editors, research stated, "Discrimination of glycoproteins with different glycans is a significant but difficult issue. We presented here a new strategy for strengthening the discrimination of glycoproteins by introducing a new signaling channel, fluorescence polarization (FP), into a 'single probe with three signaling channels' sensor array."

Our news journalists obtained a quote from the research from Nankai University, "The single probe was aminophenylboronic-acid-conjugated poly(acrylic acid)-Mn-doped ZnS quantum dots, and the three signaling channels were FP, room temperature phosphorescence and light scattering. Ten glycoproteins, including ovalbumin, fibrinogen, transferrin, horseradish peroxidase, vascular endothelial growth factor, immunoglobulin G, avidin, hyaluronidase, cellulase R-10, and glucose oxidase, were involved for evaluating the discriminating capability. The introduction of the FP signaling channel improved the discriminating power of the sensor array, so that the 10 glycoproteins at 0.15 mu M could be well discriminated both in PBS buffer and in the presence of human serum sample. The identification accuracy of the unknown samples was 96.25% (77 out of 80) at the 0.15 mu M level and 97.50% (78 out of 80) at the 0.2 mu M level."

According to the news editors, the research concluded: "The integration of the signaling patterns with different responsive principles was demonstrated as the promising way to enhance the discrimination power of the single-probe-based sensor arrays."

For more information on this research see: Aminophenylboronic-Acid-Conjugated Polyacrylic Acid-Mn-Doped ZnS Quantum Dot for Highly Sensitive Discrimination of Glycoproteins. Analytical Chemistry, 2014;86(12):5706-5712. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

Our news journalists report that additional information may be obtained by contacting L.J. Sang, Nankai Univ, Coll Chem, Res Center Analyt Sci, Tianjin 300071, People's Republic of China (see also Proteins).

Keywords for this news article include: Tianjin, People's Republic of China, Asia, Emerging Technologies, Glycoconjugates, Glycoproteins, Nanotechnology, Quantum Dots

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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