Study Data from Institute of High Energy Physics Update Understanding of Extracellular Matrix Proteins (Regulation on mechanical properties of collagen: enhanced bioactivities of metallofullerol)
By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Proteins. According to news originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Increased mechanical property of extracellular matrix (ECM) around tumor tissue is highly correlated to the progression of cancer, and now its efficient regulation is still a challenge. Here, we report that Gd@C82(OH)22-collagen composites greatly suppress the malignant progression of cancer cells in vitro, and the metallofullerol can efficiently reduce the mechanical property of collagen matrix."
Our news journalists obtained a quote from the research from the Institute of High Energy Physics, "Further study indicates that Gd@C82(OH)22 can firmly bind to tropocollagen, facilitate the nuclei and microfibril formation. The interference to interactions among tropocollagens leads to decreased amount and disturbed structure of collagen fibers. C60(OH)24, the fullerol counterpart of Gd@C82(OH)22, is studied in parallel and their impacts on collagen are strikingly modest. The comparison data reveals that the enhanced bioactivity of Gd@C82(OH)22 is highly related with its surface-structure. This study is the first attempt to apply nanomedicines to manipulate the biophysical property of collagen matrix, providing a new sight to target ECM in cancer therapy. Increased presence of 'harder' collagen in the extracellular matrix (ECM) around the tumor tissue highly correlates with cancer progression."
According to the news editors, the research concluded: "In this paper, a metallofullerol-based approach is reported as an efficient nanotechnology approach in reducing the mechanical properties of the synthesized collagen, paving the way to the development of novel anti-cancer therapies."
For more information on this research see: Regulation on mechanical properties of collagen: enhanced bioactivities of metallofullerol. Nanomedicine, 2014;10(4):783-93. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)
The news correspondents report that additional information may be obtained from Y. Song, CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Science (CAS), Beijing 100049, People's Republic of China. Additional authors for this research include M. Zhang, L. Zhao, X. Yin, J. Zhao, J. Li, R. He, Y. Chang, J. Jin, Y. Zhao, J. Li and G. Xing (see also Proteins).
Keywords for this news article include: Beijing, People's Republic of China, Asia, Cancer, Collagen, Extracellular Matrix Proteins, Oncology.
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