Studies from University of Waterloo Add New Findings in the Area of Nanoparticles (Characterization of glucose oxidation by gold nanoparticles using nanoceria)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news originating from Waterloo, Canada, by NewsRx correspondents, research stated, "Gold nanoparticles (AuNPs) can oxidize glucose, producing hydrogen peroxide and gluconic acid, which are the same products as those generated by glucose oxidase (GOx). In this regard, AuNPs are a nanozyme."
Our news journalists obtained a quote from the research from the University of Waterloo, "Herein, a new colorimetric method is developed to understand the surface chemistry of gold nanoparticles for this oxidation reaction. The color of nanoceria is changed to yellow by the hydrogen peroxide generated during glucose oxidation. Using this assay, we find that adsorption of small molecules such as citrate does not deactivate AuNPs, while adsorption of polymers including serum proteins and high molecular weight polyethylene glycol inhibits glucose oxidation. In addition to glucose, AuNPs can also oxidize galactose. Therefore, this reaction is unlikely to be directly useful for glucose detection for biomedical applications. On the other hand, AuNPs might serve as a general oxidase for a broad range of substrates. The glucose oxidation reaction is slower at lower pH. Since the reaction generates an acid product, glucose oxidation becomes slower as the reaction proceeds. The effects of temperature, AuNP size, and reaction kinetics have been systematically studied."
According to the news editors, the research concluded: "This work provides new insights regarding the surface chemistry of AuNPs as a nanozyme."
For more information on this research see: Characterization of glucose oxidation by gold nanoparticles using nanoceria. Journal of Colloid and Interface Science, 2014;428():78-83. Journal of Colloid and Interface Science can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Journal of Colloid and Interface Science - www.elsevier.com/wps/product/cws_home/622861)
The news correspondents report that additional information may be obtained from N.J. Lang, University of Waterloo, Waterloo Inst Nanotechnol, Dept. of Chem, Waterloo, ON N2L 3G1, Canada. Additional authors for this research include B.W. Liu and J.W. Liu (see also Nanoparticles).
Keywords for this news article include: Waterloo, Ontario, Canada, North and Central America, Chemicals, Chemistry, Emerging Technologies, Enzymes and Coenzymes, Hydrogen Peroxide, Nanoparticle, Nanoparticles, Nanotechnology, Oxidase
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