Studies from Catholic University of Leuven Have Provided New Data on Surface Plasmon Resonance (Biosensing with SiO2-covered SPR substrates in a commercial SPR-tool)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Surface Plasmon Resonance have been published. According to news reporting from Leuven, Belgium, by NewsRx journalists, research stated, "Surface Plasmon Resonance (SPR) is a well-established technique for studying binding kinetics and is extensively used in assay development as well as in drug discovery. Many biosensors contain an oxide surface instead of the conventional Au surface typically used in SPR sensing, which may introduce additional variables when using established protocols."
The news correspondents obtained a quote from the research from the Catholic University of Leuven, "Therefore, SiOx-covered SPR substrates are of great interest as a benchmarking tool for silicon-based biosensors. Moreover, SiOx has multiple advantages over Au, for instance with respect to the thermal stability of commonly used surface coupling strategies. In this paper, the bulk sensitivity of SiO2-covered Au substrates was evaluated for use in SPR. Both theoretical simulations and experimental results showed that the presence of -10 nm of SiO2 resulted in minimal loss of bulk sensitivity compared to Au substrates. This was proven for a prostate specific antigen (PSA) recognition immuno-assay."
According to the news reporters, the research concluded: "Thus we clearly demonstrated that SiO2-covered Au substrates can be used for biosensing applications and do not generate significant differences compared to the original Au substrates."
For more information on this research see: Biosensing with SiO2-covered SPR substrates in a commercial SPR-tool. Sensors and Actuators B-Chemical, 2014;200():167-172. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Surface Plasmon Resonance).
Our news journalists report that additional information may be obtained by contacting J. Ryken, Catholic University of Leuven, Dept. of Phys & Astron, B-3001 Leuven, Belgium. Additional authors for this research include J.Q. Li, T. Steylaerts, R. Vos, J. Loo, K. Jans, W. Van Roy, T. Stakenborg, P. Van Dorpe, J. Lammertyn and L. Lagae.
Keywords for this news article include: Leuven, Belgium, Europe, Bioengineering, Bionanotechnology, Biosensing, Biotechnology, Nanobiotechnology, Nanotechnology, Surface Plasmon Resonance
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