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Studies from Autonomous University Further Understanding of Breast Cancer (A novel quinoline molecular probe and the derived functionalized gold...

July 29, 2014



Studies from Autonomous University Further Understanding of Breast Cancer (A novel quinoline molecular probe and the derived functionalized gold nanoparticles: Sensing properties and cytotoxicity studies in MCF-7 human breast cancer cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology have been published. According to news reporting originating in Barcelona, Spain, by NewsRx journalists, research stated, "A highly selective quinoline-based fluorescent sensor L was designed, prepared and used to monitor zinc ions in Goldfish (Carassius auratus) as model of vertebrate organism. Modified gold nanoparticles having functional quinoline molecules (GNPs@L) were also synthesized and their sensing properties towards different metal ions were also explored in solution, showing high selectively towards the toxic and heavy metal ion mercury."

The news reporters obtained a quote from the research from Autonomous University, "Cell proliferation kit XTT that employs 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide salt (XTT) was used in order to investigate the cytotoxicity of compound L and GNPs@L on the MCF-7 breast cancer cells, showing significant cytotoxicity in comparison with similar reported systems. It was observed that L and GNPs@L compounds induced apoptosis in MCF-7 cancer cells."

According to the news reporters, the research concluded: "The cellular uptake of the hybrid system GNPs@L was studied using confocal laser scanning microscopy (CLSM)."

For more information on this research see: A novel quinoline molecular probe and the derived functionalized gold nanoparticles: Sensing properties and cytotoxicity studies in MCF-7 human breast cancer cells. Journal of Inorganic Biochemistry, 2014;137():115-122. Journal of Inorganic Biochemistry can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Journal of Inorganic Biochemistry - www.elsevier.com/wps/product/cws_home/505772)

Our news correspondents report that additional information may be obtained by contacting C. Nunez, Autonomous University of Barcelona, Dept. of Bioquim & Biol Mol, E-08193 Barcelona, Spain. Additional authors for this research include E. Oliveira, J. Garcia-Pardo, M. Diniz, J. Lorenzo, J.L. Cape and C. Lodeiro (see also Oncology).

Keywords for this news article include: Barcelona, Spain, Europe, Breast Cancer, Emerging Technologies, Nanoparticle, Nanotechnology, Oncology, Women's Health

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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