Researchers from University of Michigan Provide Details of New Studies and Findings in the Area of Viral RNA (Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Viral RNA. According to news reporting from Ann Arbor, Michigan, by NewsRx journalists, research stated, "Most antiviral treatment options target the invading pathogen and unavoidably encounter loss of efficacy as the pathogen mutates to overcome replication restrictions. A good strategy for circumventing drug resistance, or for pathogens without treatment options, is to target host cell proteins that are utilized by viruses during infection."
The news correspondents obtained a quote from the research from the University of Michigan, "The small molecule WP1130 is a selective deubiquitinase inhibitor shown previously to successfully reduce replication of noroviruses and some other RNA viruses. In this study, we screened a library of 31 small molecule derivatives of WP1130 to identify compounds that retained the broad-spectrum antiviral activity of the parent compound in vitro but exhibited improved drug-like properties, particularly increased aqueous solubility. Seventeen compounds significantly reduced murine norovirus infection in murine macrophage RAW 264.7 cells, with four causing decreases in viral titers that were similar or slightly better than WP1130 (1.9 to 2.6 log scale). Antiviral activity was observed following pre-treatment and up to 1 hour postinfection in RAW 264.7 cells as well as in primary bone marrow-derived macrophages. Treatment of the human norovirus replicon system cell line with the same four compounds also decreased levels of Norwalk virus RNA. No significant cytotoxicity was observed at the working concentration of 5 M for all compounds tested. In addition, the WP1130 derivatives maintained their broad-spectrum antiviral activity against other RNA viruses, Sindbis virus, LaCrosse virus, encephalomyocarditis virus, and Tulane virus."
According to the news reporters, the research concluded: "Thus, altering structural characteristics of WP1130 can maintain effective broad-spectrum antiviral activity while increasing aqueous solubility."
For more information on this research see: Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses. Plos One, 2014;9(4):e94491. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news journalists report that additional information may be obtained by contacting M.J. Gonzalez-Hernandez, Dept. of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States. Additional authors for this research include A. Pal, K.E. Gyan, M.E. Charbonneau, H.D. Showalter, N.J. Donato, M. O'Riordan and C.E Wobus (see also Viral RNA).
Keywords for this news article include: Ann Arbor, Michigan, United States, North and Central America, Viral RNA.
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