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Researchers from Nova Southeastern University Discuss Findings in Immunoglobulins (Targeted nanoparticles for simultaneous delivery of...

July 30, 2014



Researchers from Nova Southeastern University Discuss Findings in Immunoglobulins (Targeted nanoparticles for simultaneous delivery of chemotherapeutic and hyperthermia agents - An in vitro study)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Immunology have been presented. According to news reporting originating in Fort Lauderdale, Florida, by NewsRx journalists, research stated, "The purpose of this study was to prepare targeted Poly lactide-co-glycolide (PLGA) nanoparticles with simultaneous entrapment of indocyanine green (ICG) and doxorubicin (DOX) by surface decorating them with tumor specific monoclonal antibodies in order to achieve simultaneous therapy and imaging. ICG was chosen as an imaging and hyperthermia agent and DOX was used as a chemotherapeutic agent."

The news reporters obtained a quote from the research from Nova Southeastern University, "ICG and DOX were incorporated into PLGA nanoparticles using the oil-in-water emulsion solvent evaporation technique. These nanoparticles were further surface decorated with antibodies against Human Epithelial Receptor-2 (HER-2) using carbodiimide chemistry. The uptake of antibody conjugated ICG-DOX-PLGA nanoparticles (AIDNP) was enhanced in SKOV-3 (HER-2 overexpressing cell lines) compared to their non-conjugated counterparts (ICG-DOX-PLGA nanoparticles (IDNP)). The uptake of antibody conjugated ICG-DOX-PLGA nanoparticles, however, was similar in MES-SA and MES-SA/Dx5 cancer cells (HER-2 negative cell lines), which were used as negative controls. The cytotoxicity results after laser treatment (808 nm, 6.7 W/cm(2)) showed an enhanced toxicity in treatment of SKOV-3. The negative controls exhibited comparable cytotoxicity with or without exposure to the laser."

According to the news reporters, the research concluded: "Thus, this study showed that these antibody conjugated ICG-DOX-PLGA nanoparticles have potential for combinatorial chemotherapy and hyperthermia."

For more information on this research see: Targeted nanoparticles for simultaneous delivery of chemotherapeutic and hyperthermia agents - An in vitro study. Journal of Photochemistry and Photobiology B-Biology, 2014;136():81-90. Journal of Photochemistry and Photobiology B-Biology can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Immunology).

Our news correspondents report that additional information may be obtained by contacting S. Srinivasan, Nova SE Univ, Phys Therapy Department, Fort Lauderdale, FL 33328, United States. Additional authors for this research include R. Manchanda, T.J. Lei, A. Nagesetti, A. Fernandez-Fernandez and A.J. McGoron.

Keywords for this news article include: Fort Lauderdale, Florida, United States, North and Central America, Antibodies, Blood Proteins, Emerging Technologies, Immunoglobulins, Immunology, Nanoparticle, Nanotechnology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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