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Researchers from Chungnam National University Report Recent Findings in Cancer Gene Therapy (Clinicopathological roles of S100A8 and S100A9 in...

July 28, 2014



Researchers from Chungnam National University Report Recent Findings in Cancer Gene Therapy (Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro)

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Biotechnology. According to news reporting from Taejon, South Korea, by NewsRx journalists, research stated, "S100A8 and S100A9 are members of the S100 protein family and exist in neutrophils, monocytes, and macrophages. Recent studies have shown that S100A8 and S100A9 are associated with various neoplastic disorders; however, their roles in cutaneous squamous cell carcinoma (SCC) are not well defined."

The news correspondents obtained a quote from the research from Chungnam National University, "To investigate the expression and function of S100A8 and S100A9 in skin tumors, we examined the expression levels of S100A8 and S100A9 between premalignant and malignant skin tumors and investigated the functional roles of S100A8 and S100A9 in vitro and in vivo using recombinant adenovirus expressing S100A8 or S100A9. The immunopositive staining rates and intensities of S100A8 and S100A9 were higher in SCC than in premalignant skin tumors. When S100A8 and/or S100A9 were overexpressed in SCC12 cells using a recombinant adenovirus, cell growth and motility were increased. Similarly, when mouse skin was intradermally injected with SCC12 cells overexpressing S100A8 and/or S100A9, there were remarkable increases in tumor growth and volume. Both S100A8 and S100A9 are highly expressed in cutaneous SCC and play important roles in tumorigenesis."

According to the news reporters, the research concluded: "We suggest that S100A8 and S100A9 may be potential therapeutic targets for the prevention or treatment of SCC in skin."

For more information on this research see: Clinicopathological roles of S100A8 and S100A9 in cutaneous squamous cell carcinoma in vivo and in vitro. Archives of Dermatological Research, 2014;306(5):489-496. Archives of Dermatological Research can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Archives of Dermatological Research - www.springerlink.com/content/0340-3696/)

Our news journalists report that additional information may be obtained by contacting D.K. Choi, Chungnam National University, Dept. of Pathol, Sch Med, Taejon, South Korea. Additional authors for this research include Z.J. Li, I.K. Chang, M.K. Yeo, J.M. Kim, K.C. Sohn, M. Im, Y.J. Seo, J.H. Lee, C.D. Kim and Y. Lee (see also Biotechnology).

Keywords for this news article include: Taejon, South Korea, Asia, Biotechnology, Cancer Gene Therapy, Oncology, Squamous Cell Carcinoma

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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