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Researchers from Army Academy Describe Findings in Cancer Therapy (Methotrexate-conjugated AgInS2/ZnS quantum dots for optical imaging and drug...

July 30, 2014

Researchers from Army Academy Describe Findings in Cancer Therapy (Methotrexate-conjugated AgInS2/ZnS quantum dots for optical imaging and drug delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Oncology have been published. According to news reporting from Chungli, Taiwan, by NewsRx journalists, research stated, "The ability to conjugate drugs with quantum dots (QDs) offers excellent prospects in pharmacotherapy for the improvement of diagnosis and treatment of human diseases. Here, we report a facile strategy to prepare dual-functional nanomaterials consisting of QDs and an anticancer drug."

The news correspondents obtained a quote from the research from Army Academy, "Hydrophilic AgInS2/ZnS QDs were obtained through an ultrasonication process by introducing the amphiphilic polymer, poly (maleic anhydride-alt-1-octadecene) (PMAO). Subsequently, the anticancer drug methotrexate (MTX) was covalently coupled to the surface of the AgInS2/ZnS QDs by carbodiimide chemistry. The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell proliferation assay indicated that these hydrophilic PMAO-coated AgInS2/ZnS QDs exhibited negligible cytotoxicity. Human cervical (HeLa) cancer cells had > 80% cell viability after 24 h at concentrations of up to 300 mu g/mL. Confocal laser scanning microscopy revealed that the AgInS2/ZnS QDs conjugated with MTX were taken up effectively by HeLa cells. In addition, this nanomaterial was shown to have a dose-dependent antiproliferative effect in cancer cells by the MTT assay."

According to the news reporters, the research concluded: "These important features suggest that AgInS2/ZnS QDs conjugated with MTX might be a novel candidate for cancer therapeutics and diagnosis in future."

For more information on this research see: Methotrexate-conjugated AgInS2/ZnS quantum dots for optical imaging and drug delivery. Materials Letters, 2014;128():412-416. Materials Letters can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Materials Letters -

Our news journalists report that additional information may be obtained by contacting P.J. Wu, Army Academy, Dept. of Chem Engn, Chungli 320, Taiwan. Additional authors for this research include K.L. Ou, J.K. Chen, H.P. Fang, S.H. Tzing, W.X. Lin and J.Y. Chang (see also Oncology).

Keywords for this news article include: Chungli, Taiwan, Asia, Cancer, Drug Delivery Systems, Emerging Technologies, Nanotechnology, Oncology, Quantum Dots, Quantum Physics, Therapy

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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