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Researchers at University of Oxford Target Nanoparticles (Effects of mesoporous silica nanoparticles upon the function of mammalian sperm in vitro)

July 30, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Nanoparticles. According to news reporting originating from Oxford, United Kingdom, by NewsRx correspondents, research stated, "Nanomaterial-mediated delivery represents a promising technique for reproductive biology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer. Mesoporous silica nanoparticles (MSNPs) have been characterised as a powerful and safe delivery tool, rendering them an excellent candidate for use in reproductive research."

Our news editors obtained a quote from the research from the University of Oxford, "However, their effects upon mammalian gametes with highly specialised structure and functionality remain untested. Here, we show for the first time, that spherical MSNPs with hexagonal pore symmetry, functionalised with polyethileneimine and aminopropyltriethoxysilane, and optionally loaded with two common types of cargo (nucleic acid/protein), form strong associations with boar sperm following incubation in vitro and do not exert negative effect upon the main parameters of sperm function, including motility, viability, acrosomal status and DNA fragmentation index. Our findings provide a rationale for the use of MSNPs for the transfer of investigative, diagnostic and/or therapeutic compounds into mammalian sperm. Functionalized mesoporous silica nanoparticles (MSNPs) are demonstrated as efficient agents for the transfer of investigative, diagnostic, and/or therapeutic compounds into mammalian sperm."

According to the news editors, the research concluded: "This promising technique has the potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer."

For more information on this research see: Effects of mesoporous silica nanoparticles upon the function of mammalian sperm in vitro. Nanomedicine, 2014;10(4):859-70. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)

The news editors report that additional information may be obtained by contacting N. Barkalina, Nuffield Dept. of Obstetrics and Gynaecology, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Headington, Oxford, UK. Additional authors for this research include C. Jones, J. Kashir, S. Coote, X. Huang, R. Morrison, H. Townley and K. Coward (see also Nanoparticles).

Keywords for this news article include: Oxford, United Kingdom, Europe, Emerging Technologies, Nanoparticle, Nanoparticles, Nanotechnology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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