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Researchers at University of California Target Antibiotics (Nanoparticle-stabilized liposomes for pH-responsive gastric drug delivery)

July 30, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from La Jolla, California, by NewsRx journalists, research stated, "We report a novel pH-responsive gold nanoparticle-stabilized liposome system for gastric antimicrobial delivery. By adsorbing small chitosan-modified gold nanoparticles (diameter ~10 nm) onto the outer surface of negatively charged phospholipid liposomes (diameter ~75 nm), we show that at gastric pH the liposomes have excellent stability with limited fusion ability and negligible cargo releases."

The news correspondents obtained a quote from the research from the University of California, "However, when the stabilized liposomes are present in an environment with neutral pH, the gold stabilizers detach from the liposomes, resulting in free liposomes that can actively fuse with bacterial membranes. Using Helicobacter pylori as a model bacterium and doxycycline as a model antibiotic, we demonstrate such pH-responsive fusion activity and drug release profile of the nanoparticle-stabilized liposomes. Particularly, at neutral pH the gold nanoparticles detach, and thus the doxycycline-loaded liposomes rapidly fuse with bacteria and cause superior bactericidal efficacy as compared to the free doxycycline counterpart."

According to the news reporters, the research concluded: "Our results suggest that the reported liposome system holds a substantial potential for gastric drug delivery; it remains inactive (stable) in the stomach lumen but actively interacts with bacteria once it reaches the mucus layer of the stomach where the bacteria may reside."

For more information on this research see: Nanoparticle-stabilized liposomes for pH-responsive gastric drug delivery. Langmuir, 2013;29(39):12228-33. (American Chemical Society -; Langmuir -

Our news journalists report that additional information may be obtained by contacting S. Thamphiwatana, Dept. of NanoEngineering, Moores Cancer Center, University of California, San Diego , La Jolla, California 92093, United States. Additional authors for this research include V. Fu, J. Zhu, D. Lu, W. Gao and L. Zhang (see also Drugs and Therapies).

Keywords for this news article include: La Jolla, California, United States, North and Central America, Antibiotics, Antiinfectives, Antimalarial Agents, Doxycycline, Drugs, Drugs and Therapies, Emerging Technologies, Gold Nanoparticles, Nanotechnology, Tetracyclines, Therapy.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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