Researchers at University of Akron Have Reported New Data on Cystic Fibrosis (Mathematical modelling of Pseudomonas aeruginosa biofilm growth and treatment in the cystic fibrosis lung)
By a News Reporter-Staff News Editor at Gastroenterology Week -- A new study on Lung Diseases and Conditions is now available. According to news reporting originating from Akron, Ohio, by NewsRx correspondents, research stated, "Lung failure due to chronic bacterial infection is the leading cause of death for patients with cystic fibrosis (CF). It is thought that the chronic nature of these infections is, in part, due to the increased tolerance and recalcitrant behaviour of bacteria growing as biofilms."
Our news editors obtained a quote from the research from the University of Akron, "Inhalation of silver carbene complex (SCC) antimicrobial, either encased in polymeric biodegradable particles or in aqueous form, has been proposed as a treatment. Through a coordinated experimental and mathematical modelling effort, we examine this proposed treatment of lung biofilms. Pseudomonas aeruginosa biofilms grown in a flow-cell apparatus irrigated with an artificial CF sputum medium are analysed as an in vitro model of CF lung infection. A 2D mathematical model of biofilm growth within the flow-cell is developed. Numerical simulations demonstrate that SCC inactivation by the environment is critical in aqueous SCC, but not SCC-polymer, based treatments."
According to the news editors, the research concluded: "Polymer particle degradation rate is shown to be an important parameter that can be chosen optimally, based on environmental conditions and bacterial susceptibility."
For more information on this research see: Mathematical modelling of Pseudomonas aeruginosa biofilm growth and treatment in the cystic fibrosis lung. Mathematical Medicine and Biology-A Journal of the Ima, 2014;31(2):179-204. Mathematical Medicine and Biology-A Journal of the Ima can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England (see also Lung Diseases and Conditions).
The news editors report that additional information may be obtained by contacting J.K. Miller, Univ Akron, Dept. of Chem, Akron, OH 44325, United States. Additional authors for this research include J.S. Brantner, C. Clemons, K.L. Kreider, A. Milsted, P. Wilber, Y.H. Yun, W.J. Youngs, G. Young, H.T. Badawy, A. Milsted, C. Clemons, K.L. Kreider, P. Wilber, G. Young, Y.H. Yun, P.O. Wagers and W.J. Youngs.
Keywords for this news article include: Akron, Ohio, United States, North and Central America, Cystic Fibrosis, Digestive System Diseases, Gammaproteobacteria, Gram-Negative Aerobic Bacteria, Gram-Negative Aerobic Rods and Cocci, Gram-Negative Bacterial Infections, Inborn Genetic Diseases, Lung Diseases, Lung Diseases and Conditions, Pancreatic Diseases, Pseudomonadaceae, Pseudomonas Infections, Pseudomonas aeruginosa, Respiratory Tract Diseases
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