Research Results from Institute of Pharmacology and Toxicology Update Knowledge of Goblet Cells (Secretion of intestinal goblet cells: a novel excretion pathway of nanoparticles)
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Goblet Cells. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Understanding the excretion pathway is one of the most important prerequisites for the safe use of nanoparticles in biomedicine. However, the excretion of nanoparticles in animals remains largely unknown, except for some particles very small in size."
The news correspondents obtained a quote from the research from the Institute of Pharmacology and Toxicology, "Here we report a novel natural pathway for nanoparticle excretion, the intestinal goblet cell (GC) secretion pathway (IGCSP). Direct live observation of the behavior of 30-200nm activated carbon nanoparticles (ACNP) demonstrated that ACNP microinjected into the yolk sac of zebrafish can be excreted directly through intestinal tract without involving the hepato-biliary (hap-bile) system. Histopathological examination in mice after ligation of the common bile duct (CBD) demonstrated that the intravenously-injected ACNP were excreted into the gut lumen through the secretion of intestinal GCs. ACNP in various secretion phases were revealed by histopathological examination and transmission electron microscopy (TEM). IGCSP, in combination with renal and hap-bile pathways, constitutes a complete nanoparticle excretion mechanism. Nanoparticle elimination pathways are in the forefront of interest in an effort to optimize and enable nanomedicine applications. This team of authors reports a novel natural pathway for nanoparticle excretion, the intestinal goblet cell (GC) secretion pathway (IGCSP)."
According to the news reporters, the research concluded: "Direct live observation of the behavior of activated carbon nanoparticles has shown excretion directly through the intestinal tract without involving the hepato-biliary (hap-bile) system in a zebrafish model."
For more information on this research see: Secretion of intestinal goblet cells: a novel excretion pathway of nanoparticles. Nanomedicine, 2014;10(4):839-49. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)
Our news journalists report that additional information may be obtained by contacting B. Zhao, Institute of Pharmacology and Toxicology and Key Laboratory of Nanopharmacology and NanoToxicology, Beijing Academy of Medical Sciences, Beijing, People's Republic of China. Additional authors for this research include L. Sun, W. Zhang, Y. Wang, J. Zhu, X. Zhu, L. Yang, C. Li, Z. Zhang and Y. Zhang (see also Goblet Cells).
Keywords for this news article include: Beijing, People's Republic of China, Asia, Emerging Technologies, Goblet Cells, Nanoparticle, Nanotechnology.
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