Research Conducted at School of of Chemistry and Biochemistry Has Provided New Information about Prebiotics (Spontaneous prebiotic formation of a ?-ribofuranoside that self-assembles with a complementary heterocycle)
By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Prebiotics are discussed in a new report. According to news reporting originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "The RNA World hypothesis is central to many current theories regarding the origin and early evolution of life. However, the formation of RNA by plausible prebiotic reactions remains problematic."
Our news editors obtained a quote from the research from the School of Chemistry and Biochemistry, "Formidable challenges include glycosidic bond formation between ribose and the canonical nucleobases, as well as the inability of nucleosides to mutually select their pairing partners from a complex mixture of other molecules prior to polymerization. Here we report a one-pot model prebiotic reaction between a pyrimidine nucleobase (2,4,6-triaminopyrimidine, TAP) and ribose, which produces TAP-ribose conjugates in high yield (60-90%). When cyanuric acid (CA), a plausible ancestral nucleobase, is mixed with a crude TAP+ribose reaction mixture, micrometer-length supramolecular, noncovalent assemblies are formed. A major product of the TAP+ribose reaction is a ?-ribofuranoside of TAP, which we term TARC. This nucleoside is also shown to efficiently form supramolecular assemblies in water by pairing and stacking with CA."
According to the news editors, the research concluded: "These results provide a proof-of-concept system demonstrating that several challenges associated with the prebiotic emergence of RNA, or pre-RNA polymers, may not be as problematic as widely believed."
For more information on this research see: Spontaneous prebiotic formation of a ?-ribofuranoside that self-assembles with a complementary heterocycle. Journal of the American Chemical Society, 2014;136(15):5640-6. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)
The news editors report that additional information may be obtained by contacting M.C. Chen, School of Chemistry and Biochemistry and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia 30332, United States. Additional authors for this research include B.J. Cafferty, I. Mamajanov, I. Gallego, J. Khanam, R. Krishnamurthy and N.V Hud (see also Prebiotics).
Keywords for this news article include: Atlanta, Georgia, United States, North and Central America, Bacterial Polysaccharides, Emerging Technologies, Nanotechnology, Prebiotics, Supramolecular.
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