News Column

Reports Outline Nanoparticles Findings from National Institute of Standards and Technology (Glucose Oxidase-Catalyzed Growth of Gold Nanoparticles...

July 29, 2014



Reports Outline Nanoparticles Findings from National Institute of Standards and Technology (Glucose Oxidase-Catalyzed Growth of Gold Nanoparticles Enables Quantitative Detection of Attomolar Cancer Biomarkers)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Nanoparticles is the subject of a report. According to news reporting originating in Gaithersburg, Maryland, by NewsRx journalists, research stated, "Ultrasensitive and quantitative detection of cancer biomarkers is an unmet challenge because of their ultralow concentrations in clinical samples. Although gold nanoparticle (AuNP)-based immunoassays offer high sensitivity, they were unable to quantitatively detect targets of interest most likely due to their very narrow linear ranges."

The news reporters obtained a quote from the research from the National Institute of Standards and Technology, "This article describes a quantitative colorimetric immunoassay based on glucose oxidase (GOx)-catalyzed growth of 5 nm AuNPs that can detect cancer biomarkers from attomolar to picomolar levels. In addition, the limit of detection (LOD) of prostate-specific antigen (PSA) of this approach (93 aM) exceeds that of commercial enzyme-linked immunosorbent assay (ELISA) (6.3 pM) by more than 4 orders of magnitude."

According to the news reporters, the research concluded: "The emergence of red or purple color based on enzyme-catalyzed growth of 5 nm AuNPs in the presence of target antigen is particularly suitable for point-of-care (POC) diagnostics in both resource-rich and resource-limited settings."

For more information on this research see: Glucose Oxidase-Catalyzed Growth of Gold Nanoparticles Enables Quantitative Detection of Attomolar Cancer Biomarkers. Analytical Chemistry, 2014;86(12):5800-5806. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

Our news correspondents report that additional information may be obtained by contacting D.B. Liu, NIST, Opt Technol Div, Phys Lab, Gaithersburg, MD 20899, United States. Additional authors for this research include J. Yang, H.F. Wang, Z.L. Wang, X.L. Huang, Z.T. Wang, G. Niu, A.R.H. Walker and X.Y. Chen (see also Nanoparticles).

Keywords for this news article include: Gaithersburg, Maryland, United States, North and Central America, Cancer, Emerging Technologies, Enzymes and Coenzymes, Gold Nanoparticles, Nanotechnology, Oncology, Oxidase

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Cancer Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters