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Reports from University Hospital Add New Data to Findings in Aspirin Therapy (TXA2 synthesis and COX1-independent platelet reactivity in...

July 30, 2014



Reports from University Hospital Add New Data to Findings in Aspirin Therapy (TXA2 synthesis and COX1-independent platelet reactivity in aspirin-treated patients soon after acute cerebral stroke or transient ischaemic attack)

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Drugs and Therapies is now available. According to news reporting originating from Valencia, Spain, by NewsRx correspondents, research stated, "The pharmacological target of aspirin is the inhibition of cyclooxygenase-1 (COX1) and thromboxane-A2 (TX) synthesis. Very few data are available on TX assessment in patients with stroke."

Our news editors obtained a quote from the research from University Hospital, "We studied platelet TX synthesis, COX1-independent platelet reactivity, the influence of platelet-erythrocyte interactions and the potential association between platelet responses and the severity of stroke, evaluated with a clinical score (NIHSS). We examined 157 aspirin-treated patients with acute stroke or TIA, 128 aspirin-free and 15 aspirin-treated healthy subjects (HS). Collagen-induced TX, platelet recruitment in whole blood and platelets erythrocytes (haematocrit 40%) were assessed in patients on daily-aspirin within three days from onset. Arachidonic-acid-, ADP-, thrombin-receptor activating peptide TRAP-, and collagen-induced aggregation were also evaluated. Partial TX inhibition (

According to the news editors, the research concluded: "Partial TX inhibition and COX1-independent platelet hyperfunction were associated with more-severe stroke."

For more information on this research see: TXA2 synthesis and COX1-independent platelet reactivity in aspirin-treated patients soon after acute cerebral stroke or transient ischaemic attack. Thrombosis Research, 2013;132(2):211-6. (Elsevier - www.elsevier.com; Thrombosis Research - www.elsevier.com/wps/product/cws_home/369)

The news editors report that additional information may be obtained by contacting J. Valles, Research Center, University Hospital La Fe, Valencia, Spain. Additional authors for this research include A. Lago, A. Moscardo, J. Tembl, V. Parkhutik and M.T Santos (see also Drugs and Therapies).

Keywords for this news article include: Valencia, Spain, Europe, Angiology, Antiplatelet Agents, Aspirin, Benzoic Acids, Carboxylic Acids, Cardiology, Coagulation Modifiers, Collagen, Drugs, Drugs and Therapies, Extracellular Matrix Proteins, Hydroxy Acids, Organic Chemicals, Pharmaceuticals, Platelet Aggregation Inhibitors, Salicylic Acids, Therapy.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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