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Reports from Chulalongkorn University Describe Recent Advances in Carbohydrate Polymers (Ethyl cellulose nanoparticles: clarithomycin encapsulation...

July 29, 2014



Reports from Chulalongkorn University Describe Recent Advances in Carbohydrate Polymers (Ethyl cellulose nanoparticles: clarithomycin encapsulation and eradication of H. pylori)

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Carbohydrate Polymers is now available. According to news reporting originating from Bangkok, Thailand, by NewsRx correspondents, research stated, "The extreme acidic environment of the stomach, its regular voidance of contents and the restricted access to the mucus covered habitat combined with the antibiotic resistance of the bacteria, all contribute to the poor success in the treatment of Helicobacter pylori gastric infections. Here, we demonstrate that by encapsulating clarithromycin into ethyl cellulose (EC) nanoparticles, the efficiency of H. pylori clearance in C57BL/6 mice infected with these bacteria was significantly improved."

Our news editors obtained a quote from the research from Chulalongkorn University, "Clarithomycin-loaded EC nanoparticles were prepared via a simple yet effective anti-solvent particle induction method, to yield sub-micron sized particles with 22.3 0.17% (w/w) clarithromycin loading at 86 0.5% (w/w) encapsulation efficiency. The particles dispersed well in water and simulated gastric fluid and gave a minimum inhibitory concentration of 0.09-0.18 ?g/ml against four strains of H. pylori."

According to the news editors, the research concluded: "Encapsulation into EC particles not only enhanced the anti-adhesion activity of clarithromycin when tested with H. pylori and Hep-2 cells, but also gave significant enhancement of H. pylori clearance in the stomach of C57BL/6 mice infected with the bacteria."

For more information on this research see: Ethyl cellulose nanoparticles: clarithomycin encapsulation and eradication of H. pylori. Carbohydrate Polymers, 2014;109():22-7. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871)

The news editors report that additional information may be obtained by contacting P. Pan-In, Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Additional authors for this research include W. Banlunara, N. Chaichanawongsaroj and S. Wanichwecharungruang (see also Carbohydrate Polymers).

Keywords for this news article include: Bangkok, Thailand, Asia, Carbohydrate Polymers.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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