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New Transcription Factors Findings from National Dong Hwa University Discussed (Occurrence of aryl hydrocarbon receptor agonists and genotoxic...

July 29, 2014



New Transcription Factors Findings from National Dong Hwa University Discussed (Occurrence of aryl hydrocarbon receptor agonists and genotoxic compounds in the river systems in Southern Taiwan)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteins have been published. According to news reporting originating from Pingtung, Taiwan, by NewsRx correspondents, research stated, "Water and sediment samples from river systems located in Southern Taiwan were investigated for the presence of aryl hydrocarbon receptor (AhR) agonists and genotoxicants by a combination of recombinant cell assays and gas chromatography-mass spectrometry analysis. AhR agonist activity and genotoxic response were frequently detected in samples collected during different seasons."

Our news editors obtained a quote from the research from National Dong Hwa University, "In particular, dry-season water and sediment samples from Erren River showed strong AhR agonist activity (201-1423 ng L-1 and 1374-5631 ng g(-1) B-naphthoflavone equivalents) and high genotoxic potential. Although no significant correlation was found between AhR agonist activity and genotoxicity, potential genotoxicants in sample extracts were suggested to be causative agents for yeast growth inhibition in the AhR-responsive reporter gene assay. After high performance liquid chromatography fractionation, AhR agonist candidates were detected in several fractions of Erren River water and sediment extracts, while possible genotoxicants were only found in water extracts. In addition, polycyclic aromatic hydrocarbons, the typical contaminants showing high AhR binding affinity, were only minor contributors to the AhR agonist activity detected in Erren River sediment extracts. Our findings displayed the usefulness of bioassays in evaluating the extent of environmental contamination, which may be helpful in reducing the chances of falsenegative results obtained from chemical analysis of conventional contaminants."

According to the news editors, the research concluded: "Further research will be undertaken to identify major candidates for xenobiotic AhR agonists and genotoxicants to better protect the aquatic environments in Taiwan."

For more information on this research see: Occurrence of aryl hydrocarbon receptor agonists and genotoxic compounds in the river systems in Southern Taiwan. Chemosphere, 2014;107():257-264. Chemosphere can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Chemosphere - www.elsevier.com/wps/product/cws_home/362)

The news editors report that additional information may be obtained by contacting P.H. Chou, Natl Dong Hwa Univ, Inst Marine Biodivers & Evolutionary Biol, Pingtung, Taiwan. Additional authors for this research include T.C. Liu, F.C. Ko, M.W. Liao, H.M. Yeh, T.H. Yang, C.T. Wu, C.H. Chen and T.Y. Tsai (see also Proteins).

Keywords for this news article include: Pingtung, Taiwan, Asia, Aryl Hydrocarbon Receptors, DNA-Binding Proteins, Hydrocarbons, Organic Chemicals, Orphan Nuclear Receptors, Transcription Factors

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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