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New Proteomics Findings from Institute of Research and Development Described (Recent developments and applications of electron transfer dissociation...

July 29, 2014



New Proteomics Findings from Institute of Research and Development Described (Recent developments and applications of electron transfer dissociation mass spectrometry in proteomics)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteomics. According to news reporting originating in Timisoara, Romania, by NewsRx journalists, research stated, "Electron transfer dissociation (ETD) has been developed recently as an efficient ion fragmentation technique in mass spectrometry (MS), being presently considered a step forward in proteomics with real perspectives for improvement, upgrade and application. Available also on affordable ion trap mass spectrometers, ETD induces specific N-C alpha bond cleavages of the peptide backbone with the preservation of the post-translational modifications and generation of product ions that are diagnostic for the modification site(s)."

The news reporters obtained a quote from the research from the Institute of Research and Development, "In addition, in the last few years ETD contributed significantly to the development of top-down approaches which enable tandem MS of intact protein ions. The present review, covering the last 5 years highlights concisely the major achievements and the current applications of ETD fragmentation technique in proteomics. An ample part of the review is dedicated to ETD contribution in the elucidation of the most common posttranslational modifications, such as phosphorylation and glycosylation. Further, a brief section is devoted to top-down by ETD method applied to intact proteins."

According to the news reporters, the research concluded: "As the last few years have witnessed a major expansion of the microfluidics systems, a few considerations on ETD in combination with chip-based nanoelectrospray (nanoESI) as a platform for high throughput top-down proteomics are also presented."

For more information on this research see: Recent developments and applications of electron transfer dissociation mass spectrometry in proteomics. Amino Acids, 2014;46(7):1625-1634. Amino Acids can be contacted at: Springer Wien, Sachsenplatz 4-6, PO Box 89, A-1201 Wien, Austria. (Springer - www.springer.com; Amino Acids - www.springerlink.com/content/0939-4451/)

Our news correspondents report that additional information may be obtained by contacting M. Sarbu, Natl Inst Res & Dev Electrochem & Condensed Matte, Timisoara 300224, Romania. Additional authors for this research include R.M. Ghiulai and A.D. Zamfir (see also Proteomics).

Keywords for this news article include: Timisoara, Romania, Europe, Proteomics

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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