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New Molecular Biology Study Findings Recently Were Reported by Researchers at University of Pittsburgh (Polymeric biomaterials for nerve...

July 29, 2014



New Molecular Biology Study Findings Recently Were Reported by Researchers at University of Pittsburgh (Polymeric biomaterials for nerve regeneration: fabrication and implantation of a biodegradable nerve guide)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Life Science Research. According to news originating from Pittsburgh, Pennsylvania, by NewsRx correspondents, research stated, "Optimizing the quantity, quality, and speed of axon regeneration is important in maximizing functional outcomes following peripheral nerve injury. When severed, injured nerves must be able to regenerate and reconnect to the structures they previously controlled within 12-18 months before sensation and motion are permanently lost."

Our news journalists obtained a quote from the research from the University of Pittsburgh, "Nerve sprouts from the proximal stump will spontaneously migrate toward the distal stump in the event of a nerve transection. However, surgical intervention remains necessary to repair transection injuries. Regeneration becomes particularly troublesome with large gaps, where autologous nerve grafts or nerve guides are used to repair transected nerves. Nerve conduits function as therapeutic adjuncts, guiding axonal regeneration across gap defects. Despite the availability of several FDA-approved nerve conduits, functional outcomes following their use remain less than optimal. Much work has been focused on developing nerve conduits to improve peripheral nerve repair outcomes."

According to the news editors, the research concluded: "This chapter describes fabrication of a poly(caprolactone) nerve guide and demonstrates its use in a rat sciatic nerve model."

For more information on this research see: Polymeric biomaterials for nerve regeneration: fabrication and implantation of a biodegradable nerve guide. Methods In Molecular Biology, 2014;1162():139-48 (see also Life Science Research).

The news correspondents report that additional information may be obtained from W.N. Sivak, Dept. of Plastic Surgery, University of Pittsburgh, 200 Lothrop Street, 1655E BST, Pittsburgh, PA, United States. Additional authors for this research include J.M. Bliley and K.G Marra.

Keywords for this news article include: Pittsburgh, Pennsylvania, United States, North and Central America, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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