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New Gastroenterology Study Results from Duke University Described (In vitro and in vivo models for the study of oral delivery of nanoparticles)

August 1, 2014

By a News Reporter-Staff News Editor at Drug Week -- Current study results on Gastroenterology have been published. According to news reporting out of Durham, North Carolina, by NewsRx editors, research stated, "Oral delivery is an attractive route to deliver therapeutics via nanoparticles due to its ease of administration and patient compliance. This review discusses laboratory techniques for studying oral delivery of nanoparticles, which offer protection of cargo through the gastrointestinal tract."

Our news journalists obtained a quote from the research from Duke University, "Some of the difficulties in modeling oral delivery include the harsh acidic environment, variable pH, and the tight monolayer of endothelial cells present throughout the gastrointestinal tract. The use of in vitro techniques including the Transwell system, simulated gastric/intestinal fluid, and diffusion chambers addresses these challenges. When studying effects after oral delivery in vivo, bioimaging of nanoparticle biodistribution using radioactive markers has been popular. Functional assays such as immune response and systemic protein concentration analysis can further define the merits of the oral delivery systems."

According to the news editors, the research concluded: "As biologics become increasingly more important in chronic therapies, nanoparticle-mediated oral delivery will assume greater prominence, and more sophisticated in vitro and in vivo models will be required."

For more information on this research see: In vitro and in vivo models for the study of oral delivery of nanoparticles. Advanced Drug Delivery Reviews, 2013;65(6):800-10. (Elsevier -; Advanced Drug Delivery Reviews -

Our news journalists report that additional information may be obtained by contacting J.M. Gamboa, Dept. of Biomedical Engineering, Duke University, 101 Science Drive, Durham, NC 27708, United States (see also Gastroenterology).

Keywords for this news article include: Durham, North Carolina, United States, North and Central America, Emerging Technologies, Gastroenterology, Nanoparticle, Nanotechnology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Drug Week

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