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New Findings on Drug Delivery Systems Discussed by Researchers at University Putra Malaysia (In vitro sustained release study of gallic acid coated...

July 30, 2014



New Findings on Drug Delivery Systems Discussed by Researchers at University Putra Malaysia (In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting originating from Selangor, Malaysia, by NewsRx correspondents, research stated, "The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively."

Our news editors obtained a quote from the research from University Putra Malaysia, "Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics."

According to the news editors, the research concluded: "Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG."

For more information on this research see: In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system. Thescientificworldjournal [electronic Resource], 2014;2014():416354 (see also Drugs and Therapies).

The news editors report that additional information may be obtained by contacting D. Dorniani, Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, 43400, Selangor, Malaysia. Additional authors for this research include A.U. Kura, S.H. Hussein-Al-Ali, M.Z. Bin Hussein, S. Fakurazi, A.H. Shaari and Z. Ahmad.

Keywords for this news article include: Selangor, Malaysia, Asia, Drug Delivery Systems, Drugs and Therapies, Emerging Technologies, Nanoparticle, Nanotechnology, Therapy.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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