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New Findings from Technical University in Pharmaceutical Research and Biopharmaceuticals Provides New Insights [Evaluation of Shirasu Porous Glass...

August 1, 2014



New Findings from Technical University in Pharmaceutical Research and Biopharmaceuticals Provides New Insights [Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions]

By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Drugs and Therapies. According to news originating from Braunschweig, Germany, by NewsRx correspondents, research stated, "Aqueous colloidal drug carrier dispersions based on nonpolar lipids are usually prepared by high energy dispersion techniques, like high-pressure homogenization. Homogenization generates high shear forces and may thus not be suitable for the processing of sensitive pharmaceutical ingredients, e.g., proteins."

Our news journalists obtained a quote from the research from Technical University, "This study investigated the general possibility to prepare lipid nanoparticle dispersions by direct and premix Shirasu Porous Glass (SPG) membrane emulsification as alternative low energy and low shear method. The influence of different emulsifiers (polysorbate 20, sorbitan oleate, poloxamer 188, sodium dodecyl sulfate, sucrose laurate), the type of lipid phase (medium chain triglycerides, soybean oil, trimyristin, glyceryl behenate, lauroyl macrogolglycerides), the pore size of the SPG membrane (0.1, 0.2, 0.3, 0.5, 1.1 mu m) and the emulsifying pressure on the particle size of the resulting dispersions was investigated. The particle size was primarily controlled by the pore size of the membrane and the emulsifying pressure. Very narrow particle size distributions with membrane pore size/mean particle size ratios of 1:0.4-1:8.2 and 1:0.4-1:2.1 were observed for the direct and the premix membrane emulsification method, respectively."

According to the news editors, the research concluded: "Due to the comparatively lower process pressures of at maximum 10 bar SPG membrane emulsification is an interesting alternative method to high-pressure homogenization."

For more information on this research see: Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions. European Journal of Pharmaceutics and Biopharmaceutics, 2014;87(1):178-186. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws_home/600120)

The news correspondents report that additional information may be obtained from S. Joseph, Technical University Carolo Wilhelmina, Inst Pharmazeut Technol, D-38106 Braunschweig, Germany (see also Drugs and Therapies).

Keywords for this news article include: Braunschweig, Germany, Europe, Drugs and Therapies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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