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New Data from University of Pavia Illuminate Findings in Pharmaceutical Research and Biopharmaceuticals (Ionic polymeric micelles based on chitosan...

August 1, 2014



New Data from University of Pavia Illuminate Findings in Pharmaceutical Research and Biopharmaceuticals (Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid)

By a News Reporter-Staff News Editor at Drug Week -- Current study results on Drugs and Therapies have been published. According to news reporting from Pavia, Italy, by NewsRx journalists, research stated, "Chitosan is well known for its positive properties in wound healing. Also unsaturated fatty acids are described as able to accelerate tissue repairing mechanisms."

The news correspondents obtained a quote from the research from the University of Pavia, "In this work hydrophobically modified chitosan was obtained by ionic interaction with either oleic or linoleic acid. In aqueous environment self-assembling into nanoparticles occurred. The presence of hydrophobic domains, similar to those present in polymeric micelles, was demonstrated by changes in pyrene spectra. Both oleate and linoleate derivatives showed mucoadhesion behaviour. Cytotoxicity tests on human dermal fibroblasts demonstrated good biocompatibility of especially oleate derivatives. Clarithromycin, a poorly soluble model drug proposed for use in infected wounds was successfully encapsulated in both oleic and linoleic based polymeric micelles. The ionic structure of the carriers is responsible for their loosening at neutral pH and in the presence of salts."

According to the news reporters, the research concluded: "This behaviour should impair parenteral administration of the systems, but can be useful for topical delivery where the micelle components, chitosan and fatty acid, can play a positive role in dermal regeneration and tissue repairing."

For more information on this research see: Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid. European Journal of Pharmaceutics and Biopharmaceutics, 2014;87(1):101-106. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws_home/600120)

Our news journalists report that additional information may be obtained by contacting M.C. Bonferoni, University of Pavia, Dept. of Drug Sci, I-27100 Pavia, Italy. Additional authors for this research include G. Sandri, E. Dellera, S. Rossi, F. Ferrari, M. Mori and C. Caramella (see also Drugs and Therapies).

Keywords for this news article include: Pavia, Italy, Europe, Drugs and Therapies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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